Results 221 to 230 of about 6,227 (291)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

AI-enabled workforce integration: blended human resource contribution rate in Chinese companies. [PDF]

Front Artif Intell
Zhang K, Wu C, Ge M, Liu T.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Parental major life events before or during pregnancy and autistic behaviors among preschool children. [PDF]

Sci Rep
Liu W, Wu Y, Wen D, Chen H, Liu J, Wu S, Lin J, Liu Z, Wang X, Li L, Zeng F, Chen R, Jin Y.   +12 more
europepmc   +1 more source

Freelancing Platform

B V, Srikanth, J, Mithun Reddy, E, Sai Teja, R, Sathwik Reddy   +3 more
openaire   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Parents' knowledge, attitudes, and practices regarding the impact of children's oral habits on the development of the orofacial system. [PDF]

BMC Public Health
Zhang N, Guo J, Yang B, Fang S, Cheng Y, Chen J, Sun B, Li Y.   +7 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Innovation hubs and young adults' employment in fragile and conflict-affected Somalia: evidence from Mogadishu. [PDF]

Front Sociol
Ahmed AA, Isak ML.
europepmc   +1 more source

A study on the current situation and influencing factors of childcare service demand for parents of infants aged 0-3 years in Ningbo city of China. [PDF]

Front Public Health
Sun N, Li H, Zhu C, Zhong K, Yang S, Li Q.   +5 more
europepmc   +1 more source