Results 151 to 160 of about 4,608 (301)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Freeness soft sensor in tmprefining
, 2004 A study of the refined pulp quality control was started in 1998 at UPM-Kymmene Kaipola paper mill in Finland. Studied refiners were Metso Paper SD-65 including both main and reject refining.
Kortelainen, Juha +4 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Quantum signatures of chaos from free probability
Journal of High Energy PhysicsA classical dynamical system can be viewed as a probability space equipped with a measure-preserving time evolution map, admitting a purely algebraic formulation in terms of the algebra of bounded functions on the phase space.
Hugo A. Camargo +4 more
doaj +1 more source
, 2013 A series of papers have appeared investigating the ability of various species to learn context-free languages. From a computational point of view, the experiments in this tradition suffer from a number of problems concerning the stimuli used in the training phase of the experiments, the controls presented in the test phase of the experiments, and the ...
openaire +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Envy-Freeness and Implementation in Large Economies [PDF]
, 2003 We show that an asymptotic envy-freeness is a necessary condition for a form of robust approximate implementation in large ...
Jackson, Matthew O., Kremer, Ilan
core
In this brief note we show that for a field extension $K/F$, $S=K[\![\mathbf{x}]\!]$ is a free $R=F[\![\mathbf{x}]\!]$-module precisely when $K/F$ is finite. We then raise the question \emph{what is the projective dimension of $S$?}
openaire +2 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source