Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher +10 more
wiley +1 more source
Investigation on a Freeze-Drying Process for Long-Term Stability of mRNA-LNPs. [PDF]
Vaccines (Basel)Khan MDFH +2 more
europepmc +1 more source
Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall +16 more
wiley +1 more source
Urinary placental growth factor stability as a critical factor in the reliability of preeclampsia diagnosis. [PDF]
Biochem Med (Zagreb)Martinez-Marzo E +6 more
europepmc +1 more source
Errata and corrigenda: Climate change and biodiversity in the Arctic-Nordic perspectives (vol 26, pg 96, 2007) [PDF]
, 2008 Wookey, P. A.
core +1 more source
Mission safety evaluation report for STS-37, postflight edition [PDF]
STS-37/Atlantis was launched on April 5, 1991 from Kennedy Space Center launch complex 39B at 9:23 a.m. Eastern Standard Time (EST). Launch was delayed 4 minutes 45 seconds because of safety concerns about the low cloud ceiling and the wind direction in ...
Finkel, Seymour I., Hill, William C.
core +2 more sources
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Comprehensive evaluation of the environmental performance and durability of biochar-incorporated concrete. [PDF]
Sci RepKang SB, Woo JS, Pyo M, Yun HD, Choi W.
europepmc +1 more source