Results 71 to 80 of about 11,085 (261)

What is the therapeutic mechanism of pedunculopontine nucleus stimulation in Parkinson's disease?

Neurobiology of Disease, 2019
Pedunculopontine nucleus (PPN) deep brain stimulation (DBS) is an experimental treatment for Parkinson's disease (PD) which offers a fairly circumscribed benefit for gait freezing and perhaps balance impairment.
Wesley Thevathasan, Elena Moro
doaj   +1 more source

Cueing for Freezing of Gait

The Neurologist, 2012
Visual cues can ameliorate freezing of gait, an incapacitating symptom frequently seen in patients with parkinsonism. Here, we describe a patient with severe freezing of gait, who responded well to 3-dimensional cues, but not to 2-dimensional visual cues. We discuss the potential implications of this phenomenon.
Snijders, A.H., Snijders, A.H., Jeene, P., Nijkrake, M.J., Nijkrake, M.J., Abdo, W.F., Bloem, B.R.   +6 more
openaire   +4 more sources

Nonlocomotory Robotic Strategies for Dynamic Rotation Control in Terrestrial Robots: A Review

Advanced Robotics Research, EarlyView.
Terrestrial robots increasingly require rapid body rotation to maintain stability and agility in complex environments. This review shows nonlocomotory rotational control strategies that operate without ground contact, including reaction wheels, tails, bars, limbs, and thrusters.
Y. Liang, J. An, X. Zheng, D. Wang, S. Wang, X. Wang, P. Zhu, J. Pei, S. Li, J. Paripurana, Y. Han, Z. Tang, X. Gan, Q. He, X. Ma   +14 more
wiley   +1 more source

Hypokinesia upon pallidal deep brain stimulation of dystonia: support of a GABAergic mechanism

Frontiers in Neurology, 2013
In the past, many studies have documented the beneficial effects of deep brain stimulation (DBS) in the globus pallidus internus for treatment of primary segmental or generalized dystonia.
Florian eAmtage, Thomas J Feuerstein, Simone eMeier, Thomas eProkop, Tobias ePiroth, Marcus O Pinsker   +5 more
doaj   +1 more source

A Pollen‐Enhanced Bionic Mechanoreceptor Induced by Asymmetric Ionic Convection in Hydrogel for Sensory‐Augmented Prostheses

Advanced Science, EarlyView.
This work proposed a pollen‐enhanced bionic mechanoreceptor based on ionic convection. Leveraging the ion anchoring effect of the pollen particle, the output performance could be ∼12 times higher than the original state. By employing deep learning models as AI brains, the feasibility of a sensory‐augmented prosthesis consisting of a pollen‐enhanced ...
Zi Hao Guo, Jingyu Deng, Yanzhang Xu, Chenchen Zhou, Yangshi Shao, Xiong Pu, Munho Kim, Namjoon Cho   +7 more
wiley   +1 more source

Freezing of gait: a practical approach to management

The Lancet Neurology, 2015
Freezing of gait is a common and disabling symptom in patients with parkinsonism, characterised by sudden and brief episodes of inability to produce effective forward stepping. These episodes typically occur during gait initiation or turning. Treatment is important because freezing of gait is a major risk factor for falls in parkinsonism, and a source ...
Nonnekes, J.H., Snijders, A.H., Nutt, J.G., Deuschl, G., Giladi, N., Bloem, B.R.   +5 more
openaire   +3 more sources

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Towards Real-Time Prediction of Freezing of Gait in Patients With Parkinson’s Disease: Addressing the Class Imbalance Problem

Sensors, 2019
Freezing of gait (FoG) is a common motor symptom in patients with Parkinson’s disease (PD). FoG impairs gait initiation and walking and increases fall risk.
Nader Naghavi, Aaron Miller, Eric Wade
doaj   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Variable initial swing side and prolonged double limb support represent abnormalities of the first three steps of gait initiation in patients with Parkinson’s disease with freezing of gait

Frontiers in Neurology, 2011
This study investigated abnormalities of the first three steps of gait initiation in patients with Parkinson’s disease without freezing of gait (PD-FOG) and investigated which abnormalities are related to FOG.
Yohei eOkada, Yohei eOkada, Takahiko eFukumoto, Katsuhiko eTakatori, Koji eNagino, Koichi eHiraoka   +5 more
doaj   +1 more source