Results 211 to 220 of about 1,249,488 (339)

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Proline-Nitrogen Metabolic Coordination Mediates Cold Priming-Induced Freezing Tolerance in Maize. [PDF]

Plants (Basel)
Gai Z, Liu L, Zhang N, Liu J, Cai L, Yang X, Zhang A, Zhang P, Ding J, Zhang Y.   +9 more
europepmc   +1 more source

A genome-wide association study of freezing tolerance in red clover (Trifolium pratense L.) germplasm of European origin. [PDF]

Front Plant Sci, 2023
Zanotto S, Ruttink T, Pégard M, Skøt L, Grieder C, Kölliker R, Ergon Å.   +6 more
europepmc   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

<i>Saussurea involucrata CML6</i> Enhances Freezing Tolerance by Activating Antioxidant Defense and the CBF-COR Pathway in Plants. [PDF]

Plants (Basel)
Hou M, Kong H, Li J, Xia W, Zhu J.
europepmc   +1 more source

Light Quality Modulates Plant Cold Response and Freezing Tolerance. [PDF]

Front Plant Sci, 2022
Kameniarová M, Černý M, Novák J, Ondrisková V, Hrušková L, Berka M, Vankova R, Brzobohatý B.   +7 more
europepmc   +1 more source

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

A horizontally transferred bacterial gene aids the freezing tolerance of Antarctic bdelloid rotifers. [PDF]

Proc Natl Acad Sci U S A
Raymond JA.
europepmc   +1 more source

Protective Strategies of Haberlea rhodopensis for Acquisition of Freezing Tolerance: Interaction between Dehydration and Low Temperature. [PDF]

Int J Mol Sci, 2022
Georgieva K, Mihailova G, Fernández-Marín B, Bertazza G, Govoni A, Arzac MI, Laza JM, Vilas JL, García-Plazaola JI, Rapparini F.   +9 more
europepmc   +1 more source

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source