Results 51 to 60 of about 736,311 (296)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Cytosolic proline is required for basal freezing tolerance in Arabidopsis

, 2022
The amino acid proline accumulates in many plant species under abiotic stress conditions, and various protective functions have been proposed. During cold stress, however, proline content in Arabidopsis thaliana does not correlate with freezing tolerance.
Dietmar Funck, Hoermiller, Imke I., Henrik May, Heyer, Arnd G., Lilli Schönewolf, Schönewolf, Lilli, Funck, Dietmar, May, Henrik, Imke I. Hoermiller, Arnd G. Heyer   +9 more
core   +1 more source

Freezing tolerance and proline content of in vitro selected hydroxyproline resistant winter oilseed rape

Czech Journal of Genetics and Plant Breeding, 2010
Twelve doubled haploid (DH) winter oilseed rape plants with altered levels of proline and/or freezing tolerance were obtained by in vitro selection for resistance to trans-4-hydroxy-l-proline (Hyp) in five segregating microspore populations.
Anna JANSKÁ, Sylva ZELENKOVÁ, Miroslav KLÍMA, Miroslava VYVADILOVÁ, Ilja T. PRÁŠIL   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Increasing Freezing Tolerance: Kinase Regulation of ICE1 [PDF]

, 2015
Cold temperatures trigger the ICE1-CBF-COR transcriptional cascade in plants, which reprograms gene expression to increase freezing tolerance. In this issue of Developmental Cell, Ding et al.
Zhan, Xiangqiang, Zhu, Jian-Kang, Lang, Zhaobo   +2 more
core   +1 more source

Enhancing Freezing Stress Tolerance through Regulation of the Ubiquitin–Proteasome System in Saccharomyces cerevisiae

Fermentation
The baking industry is experiencing significant growth, primarily due to the widespread adoption of frozen dough baking. However, this process can negatively impact the fermentation ability of yeast, as freezing can induce stress in yeast cells.
Ryoya Tanahashi, Akira Nishimura, Kyoyuki Kan, Natsumi Ishizaki, Shiho Fujishima, Hisanori Endo, Hiroshi Takagi   +6 more
doaj   +1 more source

Hydrogen Peroxide and Abscisic Acid Mediate Salicylic Acid-Induced Freezing Tolerance in Wheat

Frontiers in Plant Science, 2018
Salicylic acid (SA) can induce plant resistance to biotic and abiotic stresses through cross talk with other signaling molecules, whereas the interaction between hydrogen peroxide (H2O2) and abscisic acid (ABA) in response to SA signal is far from clear.
Weiling Wang, Xiao Wang, Mei Huang, Jian Cai, Qin Zhou, Tingbo Dai, Weixing Cao, Dong Jiang   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Mechanisms underlying insect freeze tolerance

Biological Reviews, 2018
ABSTRACTFreeze tolerance – the ability to survive internal ice formation – has evolved repeatedly in insects, facilitating survival in environments with low temperatures and/or high risk of freezing. Surviving internal ice formation poses several challenges because freezing can cause cellular dehydration and mechanical damage, and restricts the ...
Jantina Toxopeus, Brent J. Sinclair
openaire   +4 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source