Results 171 to 180 of about 75,053 (236)

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Spatial immune profiling complements genomic sequencing in biliary tract cancer: hypothesis-generating use cases. [PDF]

ESMO Gastrointest Oncol
Barsch M, Godbole I, Metzger P, Benzing M, Klaas L, Decker A, Dammer A, Weiß J, Dopfer EP, Gräßel L, Kuehn J, Miething C, Becker H, Lassmann S, Bronsert P, Schultheis AM, Werner M, Boerries M, Duyster J, Thimme R, Hofmann M, Quante M, Bengsch B.   +22 more
europepmc   +1 more source

Factors Affecting Surgical Outcomes Following Rotationplasty in Paediatric Sarcoma: A Literature Review

ANZ Journal of Surgery, EarlyView.
Rotationplasty is a durable limb‐salvage option for paediatric lower‐limb sarcoma. Across 58 studies and 1,217 patients, long‐term functional, psychosocial, and quality‐of‐life outcomes were favourable, often surpassing amputation and endoprosthetic reconstruction.
Rachel H. Ko, Stewart Morrison, Daniel J. Wilks   +2 more
wiley   +1 more source

Design of a fixture for precise perpendicular cuts in bone-implant sample preparation. [PDF]

BMC Res Notes
Genchev M, Riedel B, Nagels C, Schmal H, Kubosch EJ, Lanzino MC, Seidenstuecker M.   +6 more
europepmc   +1 more source

Validation of Aortic Blood Flow Simulations During Extracorporeal Circulation Using Phase Contrast Magnetic Resonance Imaging

Artificial Organs, EarlyView.
This is the first study assessing in vivo blood flow profiles during extracorporeal circulation (ECC) scenarios. Magnetic resonance imaging data served for the calibration of computational fluid dynamics algorithms, enabling accurate replication of the hemodynamic conditions.
Anna Kathrin Assmann, Sinje Reimers, Jonah S. Schrauder, Lei Qu, Xiangge Yin, Amir Moussavi, Artur Lichtenberg, Susann Boretius, Michael Neidlin, Alexander Assmann   +9 more
wiley   +1 more source

Clinical utility of sarcoma methylation classifiers in soft tissue sarcoma diagnosis. [PDF]

J Cancer Res Clin Oncol
Osterloh J, Reuss DE, von Deimling A, Füllgraf H, Heyer J, Kurowski K, Kirchhof C, Meiertoberens A, Lausch U, Schmid A, Eisenhardt SU, Braig D, Runkel A.   +12 more
europepmc   +1 more source

Extracorporeal Albumin Dialysis (OPAL) as Novel Therapeutic Bridging Option in Posthepatectomy Liver Failure

Artificial Organs, EarlyView.
Extracorporeal albumin dialysis (OPAL) effectively reduces bilirubin and improves other laboratory markers in posthepatectomy liver failure, particularly in secondary forms. It may serve as a bridging therapy to support hepatic recovery in critically ill patients, although prospective studies are needed to confirm its impact on survival.
Dorian Marckmann, Emely Wack, Luisa Schäfer, H. Christian Hillebrecht, Francesca Reimer, Gabriel Stöger, Klara Krötzsch, Magdalena Menzel, Lampros Kousoulas, Stefan Utzolino, Stefan Fichtner‐Feigl, Dawid L. Staudacher, Frederic Arnold, Thomas Welte, Philipp Holzner, Felix A. Rottmann, Christopher Berlin   +16 more
wiley   +1 more source

Screen‐Detected Coeliac Disease in a Nationally Representative Cohort: Health Indicators, Long‐Term Outcomes and Mortality

Alimentary Pharmacology &Therapeutics, EarlyView.
In a nationally representative Finnish cohort, screen‐detected coeliac disease was associated with iron deficiency, anaemia, and an atherogenic lipid profile at diagnosis, but long‐term gluten‐free treatment did not adversely affect quality of life, metabolic health, or mortality; supporting a favourable benefit‐harm balance for population‐based ...
Iida Ahonen, Kalle Kurppa, Heini Huhtala, Katri Kaukinen, Laura Kivelä, Juha Taavela   +5 more
wiley   +1 more source

Divergent Resilience of Bacterial and Fungal Gut Microbiota After Colorectal Surgery: Insights From a Prospective Longitudinal Cohort Study. [PDF]

MedComm (2020)
Wetzel S, Kohnert E, Huber R, Müller A, Knott A, Kousoulas L, Kreutz C, Badr MT, Lederer AK.   +8 more
europepmc   +1 more source

Changing climates and environments within the complex Middle to Late Pleistocene fill of an overdeepened valley at Niederweningen, Switzerland

Boreas, EarlyView.
Glacially overdeepened valleys in the northern Alpine Foreland preserve Middle to Late Pleistocene sedimentary sequences that may serve as valuable archives for reconstructing past environmental changes in response to shifts in climate. This study presents a multidisciplinary analysis of two sediment cores from the overdeepened Wehntal Valley at ...
Johannes M. Miocic, Nigel Thew, Ruth Drescher‐Schneider, Hans Rudolf Graf, Marlu Kühn, Frank Preusser, Werner H. Schoch, Lucia Wick, Heinz Furrer   +8 more
wiley   +1 more source