Results 61 to 70 of about 1,542,712 (292)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

It's not what you expected! The surprising nature of cleft alternatives in French and English [PDF]

open access: yes, 2019
While much prior literature on the meaning of clefts—such as the English form “it is X who Z-ed”—concentrates on the nature and status of the exhaustivity inference (“nobody/nothing other than X Z”), we report on experiments examining the role of the ...
Beaver, David   +2 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Origin and Position of the Translations of Three French “Commentary” by Mohammad Taghi Ghiasi [PDF]

open access: yesپژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2018
Mohammad Taghi Ghiasi started his career of translator with the translation of a number of literary criticism books, including a Commentary on the Red and the Black of Stendhal, a Commentary on The Stanger of Camus and a Commentary on the Nausea of ...
Sara Tabatabae
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

The Upside-Down Mirror, or Reality Caught in the Act [PDF]

open access: yesSlovo a Smysl
The present contribution, as part of this line of Proustian research that focuses on the specularity and auto-specularity of À la recherche du temps perdu, examines self-reflexive comparisons at a micro- or even nano-level.
Catherine Ébert-Zeminová
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Laurant Ropa and Paul Achard : second thoughts on colonial encroachments [PDF]

open access: yes, 2015
Laurent Ropa’s The Song of the Noria (1932) and Paul Achard’s Man from the Sea (1931) are twin novels which deal with the Maltese community that settled in Algeria under French rule.
Spiteri, Richard
core  

Confusing Present. Teaching (French) Literature in Silicon Valley [PDF]

open access: yes, 2017
What many of my students seem to be looking for – and indeed find – in literary texts is a sphere of concreteness that they can hold on to within their universe of randomness. I also have the impression that these students, in their reflections triggered
Gumbrecht, Hans Ulrich
core   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

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