Results 31 to 40 of about 219,799 (219)
Small-Signal Frequency Response Theory for Ideal Dc-to-Dc Converter Systems [PDF]
, 1987 The frequency response problem of switching dc-to-dc converter systems is the problem of computing the small-signal frequency response of the system with respect to its inputs.
Lau, Billy Ying Bui
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Modelling approaches for the low-frequency analysis of built-up structures with non-deterministic properties [PDF]
, 2008 Virtual simulations of the behaviour of mechanical systems are of widespread use in academia and industry. Mechanical structures are often analysed using the finite element method, where deterministic models with one particular set of physical parameters
Hinke, Lars
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Computational Methods for Periodic Systems - An Overview
, 2001 We present an up-to-date survey of numerical methods for the analysis and design of linear discrete-time periodic systems. The basic tool is the periodic Schur form and its variants, for which a certain form of numerical stability can be ...
IFAC Workshop on Periodic Control Systems (PSYCO 2001) +3 more
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Evolutionary L∞ identification and model reduction for robust control [PDF]
, 2000 An evolutionary approach for modern robust control oriented system identification and model reduction in the frequency domain is proposed. The technique provides both an optimized nominal model and a 'worst-case' additive or multiplicative uncertainty ...
Li, Y., Tan, K.C.
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Achieving Optimal Performance With Data-Driven Frequency-Based Control Synthesis Methods
Frequency Response Function (FRF)-based control synthesis methods for Linear Time-Invariant (LTI) systems have been widely used in control theory and industry.
Schuchert, Philippe Louis +1 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Controller reduction using accuracy-enhancing methods
, 2005 The efficient solution of several classes of controller approximation problems by using frequency-weighted balancing related model reduction approaches is considered.
Varga, Andras
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