Results 41 to 50 of about 254,581 (263)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

3D FREQUENCY SELECTIVE SURFACES

Progress In Electromagnetics Research C, 2012
A novel 3D Frequency Selective Surface (FSS) architecture based on a circular ring unit element is presented. The circular ring was made 3D by creating a cylindrical element of a certain length, adding an extra degree of freedom into the structure. The length of the cylinder is shown through electromagnetic simulation to have a signiflcant efiect on ...
Saidatul Norlyana Azemi, Kamran Ghorbani, Wayne S. T. Rowe   +2 more
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Angularly Stable Bandpass Frequency Selective Surface Based on Metasurface

IEEE Access, 2020
A novel bandpass frequency selective surface (FSS) working at 2.4 GHz is proposed in this paper based on metasurface with independent-polarization, wide rejection band and good angular stability.
Meijun Qu, Bin Li, Siyang Sun, Shufang Li   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Design Dual-Polarization Frequency Selective Rasorber Using Split Ring Resonators

IEEE Access, 2019
A novel dual-polarization frequency selective rasorber with one transmission band and two absorbing bands is proposed in this paper. The structure is composed of a lossless frequency selective surface layer and a resistive layer. The resistive layer is a
Ximeng Zhang, Weiwei Wu, Yuhong Ma, Chang Wang, Chenxin Li, Naichang Yuan   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Textile Frequency Selective Surface

IEEE Microwave and Wireless Components Letters, 2017
Frequency selective surfaces (FSSs) are ubiquitous on rigid substrates and increasingly on flexible polymeric substrates. Here, we developed a FSS on a textile which is neither rigid nor smooth. We fabricate a textile capable of rejecting the millimeter-wave radiation in a narrowband, while retaining desirable textile properties such as flexibility and
Michael Ghebrebrhan, Francisco Aranda, Gary Walsh, David Ziegler, Stephen Giardini, Joel Carlson, Brian Kimball, Diane Steeves, Zhiyu Xia, Shiran Yu, Edward Kingsley, Ramaswamy Nagarajan, Jojit Torcedo, Richard Williams, Andrew Gatesman   +14 more
openaire   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source