Results 101 to 110 of about 413,674 (286)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Sensors, 2018 Partial Discharge (PD) detection based on Ultra-High-Frequency (UHF) measurements in Gas-Insulated Switchgear (GIS) is often used for fault location based on extraction of Time Differences of Arrival (TDoA), and the core technique is to obtain the ...
Jun Jiang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
A Hybrid Distance Estimation for Wireless Body Sensor Networks
International Journal of Distributed Sensor Networks, 2013 Wireless body area networks become a new research issue in recent years. In this paper, we propose hibernation and distance estimation schemes for wireless USB (WUSB) over wireless body area networks (WBAN) hierarchical protocol for body sensor networks (
Kyeong Hur, Won-Sung Sohn, Jae-Kyung Kim
doaj +1 more source
RSSI-Power-Based Direction of Arrival Estimation of Partial Discharges in Substations
Energies, 2019 The localization of partial discharges in air-insulated substations using ultra-high frequency technology is widely studied for power equipment early warning purposes.
Fan Wu +5 more
doaj +1 more source
Spatial Identification Methods and Systems for RFID Tags [PDF]
, 2013 Disertační práce je zaměřena na metody a systémy pro měření vzdálenosti a lokalizaci RFID tagů pracujících v pásmu UHF. Úvod je věnován popisu současného stavu vědeckého poznání v oblasti RFID prostorové identifikace a stručnému shrnutí problematiky ...
Povalač, Aleš
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The Journal of Engineering, 2019 In allusion to fault location failure on wide area travelling-wave-based fault location methods caused by the indeterminate shortest transmission path of initial travelling wave and the inaccurate travelling wave velocity, this study proposed a novel ...
Rui Chen, Xianggen Yin, Yilin Li
doaj +1 more source