Results 101 to 110 of about 414,744 (286)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Low-frequency sound source localization as a function of closed acoustic spaces [PDF]

open access: yes, 2013
Further development of an emerging generalized theory of low-frequency sound localization in closed listening spaces is presented that aims to resolve the ambiguities inherent in previous research.
Hawksford, Malcolm O. J., Hill, Adam J.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Improving the Error of Time Differences of Arrival on Partial Discharges Measurement in Gas-Insulated Switchgear

open access: yesSensors, 2018
Partial Discharge (PD) detection based on Ultra-High-Frequency (UHF) measurements in Gas-Insulated Switchgear (GIS) is often used for fault location based on extraction of Time Differences of Arrival (TDoA), and the core technique is to obtain the ...
Jun Jiang   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Unidimensional Time Domain Quantum Optics

open access: yes, 2019
Choosing the right first quantization basis in quantum optics is critical for the interpretation of experimental results. The usual frequency basis is, for instance, inappropriate for short, subcycle waveforms.
Reulet, Bertrand, Virally, Stéphane
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

A Hybrid Distance Estimation for Wireless Body Sensor Networks

open access: yesInternational Journal of Distributed Sensor Networks, 2013
Wireless body area networks become a new research issue in recent years. In this paper, we propose hibernation and distance estimation schemes for wireless USB (WUSB) over wireless body area networks (WBAN) hierarchical protocol for body sensor networks (
Kyeong Hur, Won-Sung Sohn, Jae-Kyung Kim
doaj   +1 more source

RSSI-Power-Based Direction of Arrival Estimation of Partial Discharges in Substations

open access: yesEnergies, 2019
The localization of partial discharges in air-insulated substations using ultra-high frequency technology is widely studied for power equipment early warning purposes.
Fan Wu   +5 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

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