Results 111 to 120 of about 1,546,191 (283)

Frequency distribution

Journal of Pharmacology and Pharmacotherapeutics, 2011
  +6 more sources

GeTallele: A Method for Analysis of DNA and RNA Allele Frequency Distributions. [PDF]

Front Bioeng Biotechnol, 2020
Słowiński P, Li M, Restrepo P, Alomran N, Spurr LF, Miller C, Tsaneva-Atanasova K, Horvath A.   +7 more
europepmc   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Comprehensive Analyses of Cumulative Frequency Distributions for Solar X-Ray Flares

The Astrophysical Journal Supplement Series
We investigate the temporal evolution of cumulative flare frequency (CFF) distributions using solar X-ray data (0.5–4.0 Å) from Geostationary Operational Environmental Satellites between 1974 and 2020.
Ezgi Yoldaş, Hasan Ali Dal
doaj   +1 more source

Modeling Data with Extreme Values Using Three-Spliced Distributions

Axioms
When data exhibit a high frequency of small to medium values and a low frequency of large values, fitting a classical distribution might fail. This is why spliced models defined from different distributions on distinct intervals are proposed in the ...
Adrian Bâcă, Raluca Vernic
doaj   +1 more source

Uncovering spatial and ecological variability in gap size frequency distributions in the Canadian boreal forest. [PDF]

Sci Rep, 2020
Goodbody TRH, Tompalski P, Coops NC, White JC, Wulder MA, Sanelli M.   +5 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Genotype frequency distributions of 28 SNP markers in two commercial lines and five Chinese native chicken populations. [PDF]

BMC Genet, 2020
Li JJ, Zhang L, Ren P, Wang Y, Yin LQ, Ran JS, Zhang XX, Liu YP.   +7 more
europepmc   +1 more source