Results 141 to 150 of about 38,141 (258)

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, EarlyView.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

Enhanced Range Resolution Beamforming for Subarray-Based FDA. [PDF]

Sensors (Basel)
Wang A, Lu Y, Xu Y.
europepmc   +1 more source

Bringing cellular clarity to the cortical component of ALS with a high‐density multi‐electrode array system

The FEBS Journal, EarlyView.
High density multi‐electrode (HD‐MEA) systems enable detailed investigation of healthy and diseased brains in 2D and 3D. Here, we summarise the significance of single‐cell electrophysiology, advantages of the MEA systems with high spatio‐temporal resolution and a large number of recording sites, enabling complex network analysis.
Zehra Yagmur Erol, Christopher Quintanilla, P. Hande Ozdinler   +2 more
wiley   +1 more source

A joint range-angle-velocity estimation algorithm for FDA-MIMO radar based on graph signal processing. [PDF]

Sci Rep
Li Q, Meng A, Liao K, Xie N, Liao X, Chen H, Ghazali KHB.   +6 more
europepmc   +1 more source

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, EarlyView.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

An Angle Estimation Approach for Coherent FDA Radar Based on Transmit-Receive Sum and Difference Beamforming. [PDF]

Sensors (Basel)
Zhang J, Xu J, Liao G.
europepmc   +1 more source

Operationalizing a Decision‐Making for Adverse Event Reporting Toolkit (DART) for Aging and Serious Illness Research

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Introduction Monitoring adverse events (AEs) assures patient safety in clinical trials. Studies involving seriously ill and older adults can have a high volume of AEs related to underlying courses of illness rather than study procedures. Trials not regulated by the Food and Drug Administration (FDA) can incur excessive reporting burden beyond ...
Sara Lubetsky, Christopher Woodrell, Gabrielle Schiller, Brynn Bowman, Rachael Heitner, R. Sean Morrison, Albert L. Siu, Dalane Kitzman, Abigail Baim‐Lance   +8 more
wiley   +1 more source

Hybrid Intelligent Nonlinear Optimization for FDA-MIMO Passive Microwave Arrays Radar on Static Platforms. [PDF]

Micromachines (Basel)
Zhang Y, Li W, Yang B, Zhu C, Dong K.
europepmc   +1 more source

Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration

Journal of Periodontal Research, EarlyView.
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz   +5 more
wiley   +1 more source