Results 151 to 160 of about 1,467 (253)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Reproducibility of brain metabolite concentration measurements in lesion free white matter at 1.5 T. [PDF]

BMC Med Imaging, 2015
Busch MH, Busch MH, Vollmann W, Mateiescu S, Stolze M, Deli M, Garmer M, Grönemeyer DH.   +7 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The Big Chip: Challenge, model and architecture. [PDF]

Fundam Res
Han Y, Xu H, Lu M, Wang H, Huang J, Wang Y, Wang Y, Min F, Liu Q, Liu M, Sun N.   +10 more
europepmc   +1 more source

Impact and management of physiological calibration in spectral analysis of blood pressure variability. [PDF]

Front Physiol, 2014
Kiviniemi AM, Hintsala H, Hautala AJ, Ikäheimo TM, Jaakkola JJ, Tiinanen S, Seppänen T, Tulppo MP.   +7 more
europepmc   +1 more source

The cold re-entrant BPM [PDF]

, 2007
Baboi, N, Chel, S, Luong, M, Mildner, N, Napoly, O, Novo, J, Nölle, D, Roudier, D, Rouvière, N, Simon, C   +9 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Neurophysiological Measures of the Perception of Antismoking Public Service Announcements Among Young Population. [PDF]

Front Hum Neurosci, 2018
Cartocci G, Modica E, Rossi D, Cherubino P, Maglione AG, Colosimo A, Trettel A, Mancini M, Babiloni F.   +8 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source