Results 81 to 90 of about 1,467 (253)

Spectral Analysis and Application in Weak and High-frequency Signal of Optical Fiber Sensors [PDF]

open access: yes, 2014
在光纤传感系统中,微弱传感信号和高频传感信号的精确检测一直是研究的热点。微弱的光纤传感信号易受到检测仪器的本底噪声或者外界环境的干扰,经常淹没在噪声中,此时无法对微小传感变量进行精确判断。现今提高光纤传感器系统检测精度的方法大都为对光纤传感器的结构进行改进或对传感信号进行时域的降噪处理。在结构改进方面可以采用低噪声高放大倍数的光电转换电路或在解调系统中引入干涉仪等,但这些方式都会增加的传感系统的成本及复杂度,特别是干涉仪的引用还会降低系统的抗干扰性。对传感信号进行降噪处理如采用小波变换 ...
陈熙
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Spontaneous quantitative processing in Chinese singular and plural picture naming: An event-related potentials analysis. [PDF]

open access: yesFront Neurosci, 2022
Cui LY   +8 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

A dynamic partitioning mechanism polarizes membrane protein distribution. [PDF]

open access: yesNat Commun, 2023
Banerjee T   +8 more
europepmc   +1 more source

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