Results 71 to 80 of about 15,073,175 (287)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Current limitations of cryogenic microwave oscillator frequency stability

, 2014
Technical paperCryogenic microwave oscillators built upon sapphire loaded cavity resonators exhibit excellent levels of frequency stability. Here we present an overview of the current understanding of the various processes and noise sources that limit ...
Parker, S., John G. Hartnett, Stephen R. Parker, Ivanov, E., Tobar, M., Michael E. Tobar, Hartnett, J., Eugene N. Ivanov   +7 more
core   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Other title: Title from ODPS Ohio Emergency Management Agency newsletters home page: Ohio's emergency management news

, 2008
Biweekly, May 25, 2007-Sept. 29, 2008.; Weekly, -May 11, 2007.; Electronic coverage as of Sept. 5, 2014: Vol. 3, no. 1 (Jan. 6, 2006)-v. 5, no. 17 (Sept. 29, 2008); "A publication of the Ohio Emergency Management Agency, a division of the Ohio Department
Ohio Emergency Management Agency.
core  

Emergency Frequency Control Method for DC Island System Based on Dynamic Interaction Energy

Xiandai dianli
To address the issue of frequency instability caused by power imbalance when HVDC transmission system enters the island operation state, an emergency frequency control method based on dynamic interactive energy is proposed.
Liang WANG, Yuxin SHI, Guoming MA, Jing MA, Yufeng ZHAO, Bozong WANG, Zhongyao BAI   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Other title: Local Emergency Planning Committee Handbook

, 2014
application/pdf March 2014This handbook is designed for Local Emergency Planning Committees (LEPCs) in the State of Kansas. This handbook was developed to provide general guidance on LEPC duties, responsibilities and organization.;--Page 11.LEPC ...
Kansas. Division of Emergency Management.
core   +1 more source

Emergency Radiological Environmental Monitoring Program Report January 2009-December 2009

, 2010
The South Carolina Department of Health and Environmental Control’s (DHEC) Nuclear Response and Emergency Environmental Surveillance Section (NREES) monitors the offsite areas for the citizens in the vicinity of the four SC commercial nuclear power ...
South Carolina Department of Health and Environmental Control, Bureau of Land and Waste Management, Nuclear Response and Emergency Environmental Surveillance Section, Division of Waste Assessment & Emergency Response
core   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source