Results 101 to 110 of about 6,072,684 (259)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Frequency Regulation Control Strategy for Flywheel Energy Storage Coupled With Thermal Power Units Under Multiple Operation Stages

发电技术
ObjectivesFlywheel energy storage that assists thermal power units to participate in frequency regulation is widely used in the field of grid frequency regulation.
HONG Feng, LIANG Boyang, SUN Fengdong, LIANG Lu, WANG Wei, FANG Fang   +5 more
doaj   +1 more source

Raising public awareness and trust in transmission infrastructure projects with incentive regulation : tools and biases [PDF]

, 2018
Raising public awareness and trust in transmission infrastructure development is one of the key current challenges facing Transmission System Operators (TSOs) and other project developers. The result can be costly delays.
KEYAERTS, Nico, BHAGWAT, Pradyumna, MEEUS, Leonardo   +2 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ancillary Services in Modern Power Systems: A Practical Survey

IEEE Access
The restructuring of electricity markets has transformed the provision of ancillary services, which are essential to ensuring grid security, power quality, and reliability.
Vahid Hosseinnezhad, Mohammad Esmaeil Honarmand, Barry Hayes, Michael Phelan, Paul Conlon, Paulo Miguel Guilherme Da Costa Sobral, Pierluigi Siano   +6 more
doaj   +1 more source

Dual Frequency Regulation in Pumping Mode in a Wind–Hydro Isolated System

Energies, 2018
Frequency control is one of the most critical tasks in isolated power systems, especially in high renewable penetration scenarios. This paper presents a new hydropower pumped-storage dual control strategy that combines variable-speed-driven pumps and ...
José Ignacio Sarasúa, Guillermo Martínez-Lucas, Carlos A. Platero, José Ángel Sánchez-Fernández   +3 more
doaj   +1 more source

Children’s Physiological Regulation as a Predictor of Adaptive and Maladaptive Guilt

The present study examined associations between both children’s physiological regulation capacity and regulation when discussing disappointing a parent and children’s trait-like adaptive and maladaptive guilt.
Cooper, Arden
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source