Results 41 to 50 of about 6,855,730 (257)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Load-frequency regulation under a bilateral LFC scheme\ud using flexible neural networks [PDF]
, 2006 A new approach based on artificial Flexible Neural Networks (FNNs) is proposed to design of load frequency controller for a large scale power system in a deregulated environment.
Teshnehlab, Mohammad +4 more
core
Frequency-Power Control of VSWTG for Improved Frequency Regulation
, 2023 With increasing wind energy penetration and impending grid codes, it is important to enable wind-based power plants to provide sensitive frequency response in grids that may experience irregular frequency fluctuations with noise induced.
Asma Aziz (13059384) +1 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
ELECTRIC VEHICLE FOR FREQUENCY REGULATION OF MICROGRID
, 2021 Electric vehicles (EVs), acts as a distributed load or distributed storage when they are connected to the grid. EVs are able to provide many services like ancillary services, active power control, reactive power compensation and specially frequency ...
Madhuri P. Jadhav, V. N. Kalkhambkar
core
Flight Frequency Regulation and its Temporal Implications
, 2021 In this study, four distinct approaches for flight frequency regulation are investigated with the objective to mitigate network congestion. The approaches differ in the way how a specific number of daily flights on a route is determined: (1) directly ...
Gollnick, Volker +7 more
core +1 more source