Results 81 to 90 of about 2,112,118 (259)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mutual inductance parameter measurement and experimental research of double circuit based on different frequency method

IET Generation, Transmission & Distribution
In order to improve the measurement accuracy of mutual inductance parameters of transmission lines in the environment of double circuit power lines without power outage, this paper establishes simulation models for measuring mutual inductance parameters ...
Zeyang Lei, Xiaojun Zhang, Wenbing Zhuang, Wei Liu, Suzhou Wu, Siyi Qi   +5 more
doaj   +1 more source

Research on a monitoring point distribution method for wide-frequency oscillations in new power systems

Zhejiang dianli
Wide-frequency measurement devices can monitor wide-frequency oscillations in the power grid in real time. However， during practical engineering deployment， there is a lack of targeted guidance methods， making it difficult to comprehensively monitor ...
FAN Chen, REN Hao, LI Yudun, LIANG Zhengtang, YAO Zhiqiang, DOU Renhui   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Research on the Construction Method of the Frequency Pattern of Populations in Cities [PDF]

Proceedings of the 7th International Conference on Education, Management, Information and Mechanical Engineering (EMIM 2017), 2017
Junling Liu, Zhiqing Zhang, Huanliang Sun   +2 more
openaire   +1 more source

Research on electromagnetic localization method based on frequency component analysis

Journal of Physics: Conference Series
Abstract In pipeline transportation systems, the equipment within the pipelines undertakes critical tasks such as non-destructive testing and impurity removal. Long-term operation in high-pressure and low-temperature environments makes pipelines prone to issues such as wax deposition and pipe deformation, which can result in equipment
Longshuo Zhang, Peng Ren, Huajun Song
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source