Results 151 to 160 of about 1,329,156 (311)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Sensitivity Analysis of the Frequency Response Function of Carbon-Fiber-Reinforced Plastic Specimens for Different Direction of Carbon Fiber as Well as Spectral Loading Pattern. [PDF]
Materials (Basel), 2019 Kim CJ.
europepmc +1 more source
Vibrational performance of pedestrian bridges due to human-induced loads. [PDF]
, 1997 The vibrational performance of footbridges due to human-induced loads has been investigated, based on modal and pedestrian tests carried out on three prototype footbridges.
Pimentel, R.L., Pimentel, Roberto Leal
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Accurate Determination of the Frequency Response Function of Submerged and Confined Structures by Using PZT-Patches†. [PDF]
Sensors (Basel), 2017 Presas A +5 more
europepmc +1 more source
, 2008 We have applied a non-linear inversion technique to estimate both the earthquake source parameters and site response from a set of microearthquake records acquired by a dense seismic network, in order to provide a simple uniform site classification for ...
Cantore, Luciana
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Journal of the South African Institution of Civil Engineers, 2013 This paper investigates the natural frequencies of the profiled steel sheet dry board (PSSDB) system. Frequency response functions (FRFs), estimated experimentally, were used to determine the natural frequencies of three different PSSDB panels with ...
F A Gandomkar +3 more
doaj
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source