Results 61 to 70 of about 61,809 (262)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A Novel High Suppression Multilayer Frequency‐Selective Surface Based on Hexagonal Grids

IET Microwaves, Antennas & Propagation
This paper addresses the issue of achieving excellent overall performance for frequency selective surface (FSS) radomes. A dual‐layer frequency selective surface based on a hexagonal structure is proposed, which offers broadband suppression, roll‐off ...
Boyang Wang, Xuewu Cui, Wei Yang, Lei Han, Suli Guo   +4 more
doaj   +1 more source

Spectral domain analysis of double screen frequency selective surfaces

Journal of Microwaves, Optoelectronics and Electromagnetic Applications
This paper presents a numerical investigation for a double screen frequency selective surface (FSS) with perfectly conducting rectangular patch elements. The analysis uses a full wave technique to obtain the scattering characteristics.
Antonio Luiz Pereira de Siqueira Campos, Tércio de Lima Silva   +1 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Enhanced Gain Through a Novel Approach to Designing a Composite SWB Antenna‐FSS

IET Microwaves, Antennas & Propagation
In this paper, we propose a novel dual‐layered frequency selective surface (FSS) with a unit cell dimension (length × width × thickness) of 30λ×30λ×1.8λ, operating over a frequency range of 0.5–14.1 GHz (187%) (λ represents the wavelength at 8.3 GHz ...
Hamed Joudaki, Amir Saman Nooramin
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A Wideband Circularly Polarised High‐Gain Antenna Using Array Technology and Truncated Dielectric Plates

IET Microwaves, Antennas & Propagation
A gain enhancement method is presented for a circularly polarised (CP) wideband Fabry–Perot resonator antenna (FPRA). The proposed antenna structure consists of a multilayer configuration of closely spaced truncated dielectric plates (TDPs) and a ...
Zhixin Lei, Zhiming Liu, Bingtao Tan, Huilin Zhou, Yuhao Wang, Hao Xu   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

An ultra‐thin switched state active frequency selective surface absorber with wide bandwidth using semi‐analytical method

IET Microwaves, Antennas & Propagation
Using low‐voltage forward biased PIN diodes, an ultrathin switched states active frequency selective surface based microwave absorber is designed. Using a semi‐analytical method, the NXP#BAP70‐03 PIN diode‐based single polarised unit‐cell of the active ...
Z. A. Pandit Jibran, Kumud R. Jha, Satish K. Sharma, Anuj Shukla   +3 more
doaj   +1 more source