Results 41 to 50 of about 88,086 (210)

Minuscule Corrections to Near-surface Solar Internal Rotation Using Mode Coupling

The Astrophysical Journal Supplement Series, 2023
The observed solar oscillation spectrum is influenced by internal perturbations such as flows and structural asphericities. These features induce splitting of characteristic frequencies and distort the resonant-mode eigenfunctions.
Srijan Bharati Das, Samarth G. Kashyap, Deniz Oktay, Shravan M. Hanasoge, Jeroen Tromp   +4 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Statistics of multiple-scatterer-induced frequency splitting in whispering gallery microresonators and microlasers

New Journal of Physics, 2013
We investigate numerically and experimentally the statistics of the changes in the amount of frequency splitting upon adsorption of particles one by one into the mode volume of a whispering gallery mode (WGM) microresonator.
Lina He, Şahin Kaya Özdemir, Jiangang Zhu, Faraz Monifi, Huzeyfe Yılmaz, Lan Yang   +5 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Consistent dynamics of geodesic acoustic modes and zonal flows in toroidally rotating tokamak plasmas

Nuclear Fusion
The experimentally observed features of the spectra of the geodesic acoustic modes (GAMs) in tokamaks, such as GAM’s modulation, peak splitting, intermittency and other, have no satisfactory explanations within the framework of standard theory.
V.I. Ilgisonis, E.A. Sorokina
doaj   +1 more source

Effects of Normal-Distributed Measurement Error on Frequency Tuning for a Cylindrical Vibratory Gyroscopes

IEEE Access, 2020
Cylindrical vibratory gyroscope is a kind of mode-matched gyros, and the frequency split would affect its sensitivity significantly. Frequency tuning is a major method to decrease the split.
Youwang Hu, Kai Zeng, Hongmin Zhong, Yongping Zhou, Xiaoyan Sun, Ji'an Duan   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Simplified landscapes for optimization of shaken lattice interferometry

New Journal of Physics, 2018
Motivated by recent results using shaken optical lattices to perform atom interferometry, we explore the splitting of an atom cloud trapped in a phase-modulated (‘shaken’) optical lattice.
C A Weidner, D Z Anderson
doaj   +1 more source