Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Realization of a compact mercury ion microwave clock with frequency stability of 6.3 × 10<sup>- 16</sup>. [PDF]
Liu H +8 more
europepmc +1 more source
The great debate : Germany, Turkey and the Turks / European Stability Initiative
unknown
core +1 more source
Time Domain Measurements of Oscillators’ Frequency Stability
The thesis focuses on measurements of oscillators’ frequency stability. The theoretical part describes the basic concepts of measurement of frequency, measuring systems and measurement errors. The second part of thesis describes the design of measurement
Háněl, Petr
core
The multifaceted roles of lysosomes in cancer
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
An ultra-stable MEMS resonator with ±14 ppb frequency stability realized by nonlinearity-mediated drift suppression. [PDF]
Xu Y, Wang C, Lv J, Shao G, Wei X.
europepmc +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Quantum-driven frequency stability in Indian prospect smart grid with electric vehicle charging station integration and real-time hardware validation. [PDF]
Kaleeswari M, Sivakumar P, Aswini A.
europepmc +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
State estimation of voltage and frequency stability in solar wind integrated grids using multiple filtering techniques. [PDF]
Alharbi A.
europepmc +1 more source

