Results 151 to 160 of about 17,707,614 (353)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An AC and DC Inertia Enhancement Strategy for Bidirectional Grid-Connected Converter in DC Microgrid

Energies
The virtual synchronous generator (VSG) strategy has good application prospects as an effective measure to improve the grid inertia level. However, VSG strategy cannot stabilize DC voltage and may even affect the stability of DC voltage.
Haiguo Tang, Kehui Zhou, Yubo Huang, Zili Wang, Jiajun Fu   +4 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

A Coordinated Inertia Support Strategy for Wind–PV–Thermal Storage Systems Considering System Inertia Demand

Energies
To address the challenges to power system frequency stability under high penetration of renewable energy, this paper proposes a coordinated inertia support strategy for wind–PV–thermal storage systems, overcoming the limitations of conventional inertia ...
Tie Chen, Junlin Ren, Yue Liu, Yifan Xu, Mingrui Zhao, Jiaxin Yuan   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Modelling High-Frequency Volatility and Liquidity Using Multiplicative Error Models [PDF]

In this paper, we study the dynamic interdependencies between high-frequency volatility, liquidity demand as well as trading costs in an electronic limit order book market.
Nikolaus Hautsch, Vahidin Jeleskovic
core  

A Frequency Support Strategy for Variable Speed Wind Turbines to Avoid Secondary Frequency Drop [PDF]

With their increasing penetration into the power system, wind farms are required to participate in the provision of ancillary services such as frequency support (FS). One of the challenges associated with the participation of a wind turbine (WT) in FS is
Göhring, Johannes, Liserre, Marco, Langwasser, Marius, Mudalige, Anuradha   +3 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Physical rotor speed recovery strategy for grid-forming permanent magnet synchronous generator-based wind turbines under turbulent wind conditions

电力工程技术
After the frequency support of grid-forming permanent magnet synchronous generator-based wind turbines (GFWTs) is completed, it is necessary to promptly restore the physical rotor speed to enable the GFWTs to re-operate at the maximum power point ...
Xiaoming ZOU, Chenggen WANG, Yingjie HU
doaj   +1 more source