Results 181 to 190 of about 4,794,485 (241)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Significant Variation in Transformation Frequency in Streptococcus pneumoniae

ISME Journal, 2013
The naturally transformable bacterium Streptococcus pneumoniae is able to take up extracellular DNA and incorporate it into its genome. Maintaining natural transformation within a species requires that the benefits of transformation outweigh its costs ...
Benjamin A. Evans, Daniel E Rozen
exaly   +6 more sources

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Parameterized Resampling Time-Frequency Transform

IEEE Transactions on Signal Processing, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Tianqi Li, Qingbo He, Zhike Peng
openaire   +2 more sources

On Frequency Transformations

IEEE Transactions on Education, 1982
Frequency transformations are fundamental in the design of analog and digital filters and have been in use for many years. In the lowpass-bandpass or bandstop transformation, there are two ways to carry out the design. The filters resulting from these two ways, however, may be quite different. This fact does not seem to be widely known and, to the best
Chi-Tsong Chen, Pei-Hwa Lo
openaire   +1 more source

Tomography time-frequency transform

IEEE Transactions on Signal Processing, 2002
The paper shows that the fractional Fourier transform (FRFT) of a signal is the Radon transform of the time-frequency distribution of the same signal. Therefore, a time-frequency distribution known as the tomography time-frequency transform (TTFT) is defined as the inverse Radon transform of the FRFT of the signal.
Feng Zhang, Guoan Bi, Yan Qiu Chen
openaire   +2 more sources

Frequency Tripling Transformers

Transactions of the American Institute of Electrical Engineers, 1936
The possibility of making use of transformer harmonic phenomena for frequency multiplication has long been recognized, but practical applications have been few. Within recent years, however, several frequency tripling transformers have been built for supplying 180 cycle energy to large electric horns and similar devices from 60 cycle sources.
openaire   +1 more source