Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Cavitation-regime-controlled synergy in high-frequency sonophotocatalysis. [PDF]
Fabbrizio V +6 more
europepmc +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
From recalcitrance to precision: a robust regeneration, transformation and targeted gene editing framework in <i>Cajanus cajan</i>. [PDF]
Verma R +13 more
europepmc +1 more source
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
The Evolution of Polyclonal Competition in Aging Hematopoiesis. [PDF]
Mon Père NV, Terenzi F, Werner B.
europepmc +1 more source
SpecBEV: An End-to-End BEV 3D Object Detection Algorithm Based on Frequency-Domain Analysis and Geometric Alignment. [PDF]
Lin Y, Jia S.
europepmc +1 more source
Efficient Regeneration and Genetic Transformation System for Cymbidium kanran 'Zhushalan'. [PDF]
Cao H +6 more
europepmc +1 more source
Matrix symmetry and normality in multimode fiber transport. [PDF]
Bharadwaj S +3 more
europepmc +1 more source

