Results 61 to 70 of about 5,197 (334)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Microwave Photonic Frequency Multiplier with Low Phase Noise Based on an Optoelectronic Oscillator
PhotonicsA microwave photonic frequency multiplier with low phase noise based on an optoelectronic oscillator (OEO) is proposed and experimentally demonstrated.
Hao Luo +7 more
doaj +1 more source
Initial Assessment of Galileo Triple-Frequency Ambiguity Resolution between Reference Stations in the Hong Kong Area [PDF]
, 2021 Yangyang Li +7 more
openalex +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
A 35 GHz solid state transmitter/driver [PDF]
, 1968 Solid state transmitter/driver /multiplier/ signal source has been designed and fabricated to produce a stable crystal-controlled CW power output of 100 mw at 35 ...
De Angelis, X. A.
core +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
A Power-Combined 240 GHz Frequency-Multiplier Source for Cloud Radar Applications
IEEE Journal of MicrowavesWe present the design and testing of a >400 mW solid-state G-band transmitter developed for cloud radar applications. The source relies on GaAs on-chip power-combined Schottky diode frequency-triplers operating over a bandwidth that includes the 238 ...
Ken B. Cooper +7 more
doaj +1 more source