Results 231 to 240 of about 4,248,745 (299)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Patterns of presentation and diagnostic delays in biliary tract cancers: a real-world European study. [PDF]

ESMO Gastrointest Oncol
Martirena A, Cavka L, Guarini V, Lamarca A.   +3 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Burden and Determinants of Urinary Incontinence and Its Quality-of-Life Impact Among Women in Saudi Arabia: A Cross-Sectional Online Analysis. [PDF]

Obstet Gynecol Int
Miskeen E, Alqarni AH, Alqarni D, Ayed A, Alghanmi RD, Alsaeedi RR, Alharbi RH, Aljehani DA, Hamuman AF, Alshalan GF, Alotaibi DM, Alshahrani LA, Alwadai RI, Alqarni GAM, Safar O.   +14 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Recurrent Cutaneous Herpes Simplex Virus Infection in an Immunocompetent Young Adult: A Case Report. [PDF]

Cureus
Widjaja AM, Todd E, Baek DY, Schwartz S, Patel MK.   +4 more
europepmc   +1 more source

HLA Diversity of Over 500,000 Individuals on the DATRI Register Across 18 Regions in India. [PDF]

HLA
Agapiou M, Cereb N, Rutt C, Marsh SGE, Robinson J.   +4 more
europepmc   +1 more source

Sustained Shifts in Dietary Supplement Use Years After COVID-19: A Post-Pandemic Evaluation of Behaviors, Perceptions, and Predictors of Change in Jordan. [PDF]

Risk Manag Healthc Policy
Al-Trad EI, Abusalah MAH, Alsheikh A, Jaran AS, Rjoub YA, Ij'ear R, ALjaraedah TY, Alhawarri MB.   +7 more
europepmc   +1 more source

Geospatial modeling of environmental and socioeconomic drivers of health outcomes. [PDF]

Front Public Health
Yalali A, Rifai HS, Adepoju OE.
europepmc   +1 more source