A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
Risk factors and clinical outcomes of late-onset severe ovarian hyperstimulation syndrome in advanced maternal age women undergoing fresh embryo transfer. [PDF]
Huang Y +5 more
europepmc +1 more source
Successful pregnancy outcome after fresh embryo transfer in a dual stimulation cycle - a case report. [PDF]
Vignarajan CP, Malhotra N.
europepmc +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Correction: Predictive models for live birth outcomes following fresh embryo transfer in assisted reproductive technologies using machine learning. [PDF]
Wu S +10 more
europepmc +1 more source
Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang +16 more
wiley +1 more source
Impact of late follicular luteinizing hormone levels on live birth rate after fresh embryo transfer: a retrospective cohort study in GNRH antagonist cycles. [PDF]
Jelassi N +6 more
europepmc +1 more source
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
Correlation of the sperm DNA fragmentation index with semen parameters and its impact on fresh embryo transfer outcomes-a retrospective study. [PDF]
Wan XJ +7 more
europepmc +1 more source
Elevated follicular cortisone level is a negative predictor of clinical pregnancy in women undergoing fresh embryo transfer. [PDF]
Yang Z +5 more
europepmc +1 more source

