Results 241 to 250 of about 31,608 (289)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs

Advanced Science, EarlyView.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick, Juhi Chakraborty, Orlaith Kennedy, Hey Wei Wong, Sogol Kianersi, Daniel Kelly, Vasileios Sergis, Abhay Pandit, Andrew C. Daly   +8 more
wiley   +1 more source

Effect of diminished ovarian reserve on the outcome of fresh embryo transfer in IVF/ICSI cycles among young women: A retrospective cohort study. [PDF]

BMC Womens Health
Zhu S, Jiang W, Liao X, Sun Y, Chen X, Zheng B.   +5 more
europepmc   +1 more source

Elevated sperm DNA fragmentation is correlated with an increased chromosomal aneuploidy rate of miscarried conceptus in women of advanced age undergoing fresh embryo transfer cycle. [PDF]

Front Endocrinol (Lausanne)
Fu W, Cui Q, Bu Z, Shi H, Yang Q, Hu L.
europepmc   +1 more source

Obstetrical and Neonatal Outcomes of in vitro Fertilization Twins after Fresh Embryo Transfer versus Frozen-Thawed Embryo Transfer.

Gynecol Obstet Invest
Shlush E, Sarhan T, Aiob A, Tannus S, Mikhail SM, Lowenstein L, Sgayer I.   +6 more
europepmc   +1 more source

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Comparison of Pregnancy and Neonatal Outcomes Between Fresh Embryo Transfer and Frozen–Thawed Embryo Transfer

Therapeutic Hypothermia and Temperature Management, 2023
This study compared the pregnancy and neonatal outcomes between fresh embryo transfer and frozen-thawed embryo transfer (FET). These patients were split into two groups: the fresh embryo transfer group and the FET group. The general conditions, pregnancy outcomes, and neonatal outcomes between these groups were compared.
Man Chen, Zhi-ling Li, Hong Lin, Ru-bin Xia, Yu-lian Wang   +4 more
openaire   +2 more sources

Embryo transfer in fallow deer (): Superovulation, embryo recovery and laparoscopic transfer of fresh and cryopreserved embryos

Theriogenology, 1994
Multiple ovulation-embryo transfer (MOET) protocols for farmed fallow deer (Dama dama) were investigated in a series of 3 experiments. A total of 37 donors, of either European (D.d. dama ; n = 30) or Mesopotamian hybrid (D.d. mesopotamica x D.d. dama ; n =7) genotype, each received an intravaginal silastic device containing 0.3 g progesterone (CIDR ...
C J, Morrow, G W, Asher, D K, Berg, H R, Tervit, P A, Pugh, W H, McMillan, S, Beaumont, D R, Hall, A C, Bell   +8 more
openaire   +2 more sources

Frozen embryo transfer or fresh embryo transfer: Clinical outcomes depend on the number of oocytes retrieved

European Journal of Obstetrics, Gynecology and Reproductive Biology, 2017
To establish a safe and effective clinical transplantation strategy for determining when to prioritize frozen embryo transfers (FET) or fresh embryo transfers (ET) we conducted a retrospective analysis study, examining several key clinical outcomes.In a retrospective cohort study, 1423 patients ...
Bing Xu, Yuan Wang, Yao Lu
exaly   +3 more sources