Results 241 to 250 of about 2,755,944 (293)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Metabolic profiles of children aged 2-5 years born after frozen and fresh embryo transfer: A Chinese cohort study. [PDF]

PLoS Med
Zhou W, Feng W, Chang J, Hu J, Li F, Hu K, Jiao J, Xue X, Lan T, Wan W, Chen ZJ, Cui L.   +11 more
europepmc   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

High estradiol levels in fresh embryo transfer cycles are not associated with detrimental impact on birth outcomes. [PDF]

J Assist Reprod Genet
Lersten IL, Grau L, Jahandideh S, Devine K, Zalles L, Plosker SM, Imudia AN, Hoyos LR, Uhler ML, Homer M, Roeca C, Sammel MD, Polotsky AJ.   +12 more
europepmc   +1 more source

Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial.

BMJ
Wei D, Sun Y, Zhao H, Yan J, Zhou H, Gong F, Zhang A, Wang Z, Jin L, Bao H, Zhao S, Xiao Z, Qin Y, Geng L, Cui L, Sheng Y, Sun M, Liu P, Ding L, Liu H, Wu K, Li Y, Lu Y, Xu B, Xu B, Zhang L, Zhang H, Legro RS, Chen ZJ.   +28 more
europepmc   +1 more source

Reproductive Outcomes of Dual Trigger versus hCG Alone in Women Undergoing In Vitro Fertilization with Fresh Embryo Transfer Cycles. [PDF]

Obstet Gynecol Int
Guner FC, Ozekinci M, Mendilcioglu II, Kasabali Z.   +3 more
europepmc   +1 more source

Estradiol-to-follicle ratio on human chorionic gonadotropin day is a novel predictor of gestational diabetes mellitus in women receiving fresh embryo transfer. [PDF]

Front Endocrinol (Lausanne)
Chen H, Liu Y, Xu X, Hu L, Cai S, Gong F, Lin G, Kalk P, Krämer BK, Hocher B.   +9 more
europepmc   +1 more source

Competent blastocyst and receptivity endometrium improved clinical pregnancy in fresh embryo transfer cycles: a retrospective cohort study. [PDF]

BMC Pregnancy Childbirth
Wang L, Qiu P, Jiang L, Li P, Jiang Y.
europepmc   +1 more source

Obstetrical and Neonatal Outcomes of in vitro Fertilization Twins after Fresh Embryo Transfer versus Frozen-Thawed Embryo Transfer.

Gynecol Obstet Invest
Shlush E, Sarhan T, Aiob A, Tannus S, Mikhail SM, Lowenstein L, Sgayer I.   +6 more
europepmc   +1 more source