Results 51 to 60 of about 77,925 (341)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Understanding the microstructural evolution and fretting wear behaviors of M50 bearing steel heat treated at different temperatures

Journal of Materials Research and Technology, 2023
For M50 bearing steel, which is widely used in aerospace engine main bearings, fretting wear is an important but neglected category of wear failure during engine cold startup.
Wenting Wei, Jinzhe Ke, Zheng Liu, Guocheng Liu, Qinglong Liu, Dongsheng Qian, Lin Hua   +6 more
doaj   +1 more source

Design of a fretting fatigue test rig with compliant springs [PDF]

, 2013
Fretting is a small amplitude oscillatory movement which occurs between contacting bodies who are subjected to cyclic loading or vibrations. In the contact area arise stresses -normal and tangential- causing stress concentrations and surface degradation.
De Baets, Patrick, De Pauw, Jan, De Waele, Wim, Hojjati Talemi, Reza   +3 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Effect of Ultrasonic Surface Rolling on the Fretting Wear Property of 7075 Aluminum Alloy

Metals, 2023
This paper investigates the effect of ultrasonic surface rolling (USR) on the fretting wear properties of the 7075 aluminum alloy. A white light interferometer, Vickers hardness tester, and X-ray diffractometer were employed to comparatively analyze the ...
Qiwen Xiong, Po Zhang, Wenzheng Zhai, Xiaoshuang Luo, Zhaobing Cai, Feilong Zheng, Le Gu   +6 more
doaj   +1 more source

Predicting fretting fatigue in engineering design

International Journal of Fatigue, 2018
The progress in fretting fatigue understanding and predictability is reviewed, with engineering applications in mind. While industrial assessments often relies on simple empirical parameters, research in fretting fatigue should allow the design engineer ...
S. Sunde, F. Berto, B. Haugen
semanticscholar   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Critical Plane Methodology for Intelligent Prediction of Fretting Fatigue Lifetime Based on Shear Strain Dynamics

IEEE Access
An approach based on refined critical plane methodology to fretting fatigue lifetime prediction for structures was proposed. A new shear stress-strain interaction (SSI) critical plane equation is developed, predicated on shear strain energy for ...
Wen Zhou, Weiming Sun, Hui Xu, Guosheng Duan, Yuliang Zhang, Kun Mao, Ming Song   +6 more
doaj   +1 more source

Fretting Fatigue Experiment and Finite Element Analysis for Dovetail Specimen at High Temperature

Applied Sciences, 2021
The dovetail attachment between the turbine blade and disk for an aero-engine operates under varying centrifugal load and vibration at elevated temperatures. The fretting fatigue is prone to occur at the contact surface of the dovetail attachment.
Zhen Qu, Kaicheng Liu, Baizhi Wang, Zhiying Chen   +3 more
doaj   +1 more source