Results 31 to 40 of about 49,396 (261)

Friction Angle Prediction of Carbonate Rocks: A Case Study, Rumaila Oil Field

Iraqi Geological Journal
Friction angle (𝜑) and Cohesion (𝑐) are the most important factors to depict rock's shear strength. The friction angle (φ) expresses a unit of rock's capacity to endure shear stress. For the optimization of drilling operations, monitoring of the
Doaa Mahdi, Ayad Alrazzaq
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Method to calculate active earth pressure considering soil arching effect under nonlimit state of clay

Yantu gongcheng xuebao, 2020
By taking the limited range of clay behind the retaining wall as the research object, considering soil arching effect under non-limit state, and adopting the angle of the fracture surface obtained by the plastic upper limit theory and the variation law ...
XU Ri-qing 1, 2, XU Ye-bin 1, 2, CHENG Kang 1, 2, FENG Su-yang 1, 2, SHEN Shuo 1, 2
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Experimental Study on the Effect of Freezing and Thawing on the Shear Strength of the Frozen Soil in Qinghai-Tibet Railway Embankment

Advances in Civil Engineering, 2022
The direct shear tests of different dry density and moisture content samples at different temperatures of the frozen soil in the Qinghai-Tibet Railway embankment between Tanggula South and Anduo section were carried out to analyze the influence rules of ...
B. Wang, J. H. Gao, Y. Q. Wang, X. J. Quan, Y. W. Gong, S. W. Zhou   +5 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Investigating Calcareous and Silica Sand Behavior at Material Interfaces: A Comprehensive Study

Studia Geotechnica et Mechanica
This study centers on the crucial determination of the mobilized friction angle between soil and various materials, including steel and concrete, to enhance the modeling of soil-structure interaction.
Ahmadi Abolghasem, Nozari Mohammad Amin, Bayat Meysam, Delavari Ehsan   +3 more
doaj   +1 more source