Results 11 to 20 of about 186,196 (192)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Differential Elevational Diversity Between Overstory and Understory in Tropical Forests

Biological Diversity, EarlyView.
Tropical forest overstory and understory exhibit contrasting elevational α‐diversity patterns (unimodal vs. bimodal). Community differentiation is driven by species turnover of dominant rather than rare species, highlighting the need for vertically stratified conservation across the full elevational gradient.
Xu Li, Zhipeng Li, Kunhong You, Yang Liu, Xialan Cheng, Han Sheng, Shaohang Huang, Chushu Meng, Shu‐Yi‐Dan Zhou, Zhiyang Lie, Juxiu Liu   +10 more
wiley   +1 more source

Land birds on atolls: diversity, origin, and function

Biological Reviews, EarlyView.
ABSTRACT Oceanic islands are global hotspots of avian biodiversity and endemism. Their isolation and distinct environmental conditions have uniquely shaped the evolutionary trajectories of island birds, while, in turn, land bird communities have become critical providers of ecological functions to island ecosystems.
Sebastian Steibl, Alex S. Wegmann, Nick D. Holmes, Caitlin E. Andrews, Gérard Rocamora, Simon Ducatez, James C. Russell   +6 more
wiley   +1 more source

Exploring Cultural and Individual Differences in the Hierarchy of Moral Concern: Evidence From Student Samples Across 41 Cultural Groups

European Journal of Social Psychology, EarlyView.
ABSTRACT Many important historical and contemporary ethical debates (e.g., on slavery, abortion and environmental protection) reflect disagreements about what we owe to different groups of individuals. Recent work in moral psychology has uncovered a seemingly replicable hierarchy of moral concern, but these studies were conducted in a few countries ...
Işıl Ayça Akkuş, Charlie R. Crimston, Kelly Kirkland, Brock Bastian, Bastian Jaeger   +4 more
wiley   +1 more source

Microvascular Abnormalities in Adolescents With Anorexia Nervosa: Nailfold Video Capillaroscopic Evidence at Acute and Remission States

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Chronic malnutrition, hypothermia, and hormonal imbalance in anorexia nervosa (AN) may impair capillary structure and perfusion. This study aimed to describe the nailfold videocapillaroscopy (NVC) findings in adolescents with AN and atypical AN (AAN), to assess their association with Raynaud's phenomenon (RP), and evaluate ...
Muserref Kasap‐Cuceoglu, Melis Pehlivanturk‐Kizilkan, Erdal Sag, Seher Sener, Zeynep Balik, Sinem Akgul, Orhan Derman, Yelda Bilginer, Nuray Kanbur, Seza Özen   +9 more
wiley   +1 more source

A study of the forces generated during equine cheek tooth extraction

Equine Veterinary Journal, EarlyView.
Abstract Background Significant force is often applied when elevating equine teeth from the alveolus during extraction. No previous studies have investigated these forces. Objectives To develop a method to allow measurement of elevation forces (EF) applied during extraction, and to record forces during extraction of cheek teeth in both cadaver ...
Tom N. A. McGinley, Richard J. M. Reardon   +1 more
wiley   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Protective Effects of Fenugreek and Stevia Extracts on Dexamethasone‐Induced Testicular Damage in a Rat Model

Food Safety and Health, EarlyView.
Fenugreek and stevia extracts protect against dexamethasone‐induced testicular damage in male rats by enhancing antioxidant defenses, improving sperm quality, and restoring hormonal balance, highlighting their potential as natural therapeutics for preventing corticosteroid‐induced reproductive toxicity.
Mosab Gad, Medhat Ibrahim A. Omar, Mohammed I. Elkhateeb, Ahmed A. Zaky   +3 more
wiley   +1 more source

Spatial Patterns, Driving Forces, and Potential Grain Losses of Non‐Grain Production of Farmland in Central Yunnan Urban Agglomeration, China

Land Degradation &Development, EarlyView.
ABSTRACT The expansion of farmland non‐grain production (NGP) poses a potential threat to food security and agricultural land protection, particularly in mountainous urban agglomerations. However, the utilization patterns, driving mechanisms, and associated production‐loss effects of farmland NGP in this specific regional context remain insufficiently ...
Xiaoliang Ma, Chun Li, Shanshan Chen, Yiting Wang, Zhiqiang Lin, Liding Chen   +5 more
wiley   +1 more source

Carbon and corms: Introduced ungulates and saltwater intrusion variably impact coastal floodplain ecosystem services in the Laynhapuy Indigenous Protected Area, northern Australia

People and Nature
Carbon and biodiversity offset markets have been proposed to finance management solutions for introduced ungulates across northern Australian coastal wetlands.
Oscar Robert Jones, Lanydjana Munuŋgurr, Yanbatji Munuŋgurr, Thomas Marrkula, Brendan Wunuŋmurra, Yirralka Rangers, Lindsay Hutley, Kirstie Fryirs, Emilie Ens   +8 more
doaj   +1 more source