Results 41 to 50 of about 7,283,418 (316)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Neonatal abstinence syndrome: Diagnostic dilemmas in the maternity ward [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2015
Introduction. Neonatal abstinence syndrome (NAS) refers to a newborn neurological, gastrointestinal and/or respiratory disorder if a newborn was exposed to psychoactive substances in the intrauterine period.
Lazić-Mitrović Tanja, Miković Željko, Mandić Vesna, Hajnal-Avramović Lidija, Ćećez Đurđica, Stanimirović Aleksandar, Janković Borisav   +6 more
doaj   +1 more source

Front Cover [PDF]

Diversity and Distributions, 2016
Line‐field confocal optical coherence tomography is a new imaging technique providing in vivo three‐dimensional images of the skin. Its spatial resolution allows standard measurements as SC/epidermis thicknesses or dermal‐epidermal junction undulation as well as innovative quantification of epidermis down to the cellular level based on artificial ...
Julie Chauvel‐Picard, Vincent Bérot, Linda Tognetti, Carmen Orte Cano, Margot Fontaine, Clément Lenoir, Javiera Pérez‐Anker, Susana Puig, Arnaud Dubois, Sandra Forestier, Jilliana Monnier, Randa Jdid, Gabriel Cazorla, Mélanie Pedrazzani, Antoine Sanchez, Sébastien Fischman, Pietro Rubegni, Véronique del Marmol, Joseph Malvehy, Elisa Cinotti, Jean L. Perrot, Mariano Suppa   +21 more
openaire   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Repotrectinib (TPX-0005) Is a Next-Generation ROS1/TRK/ALK Inhibitor That Potently Inhibits ROS1/TRK/ALK Solvent- Front Mutations.

Cancer Discovery, 2018
The use of tyrosine kinase inhibitors (TKI) with activity against ALK, ROS1, or TRKA-C can result in significant clinical benefit in patients with diverse tumors harboring ALK, ROS1, or NTRK1-3 rearrangements; however, resistance invariably develops. The
A. Drilon, Sai-Hong Ignatius Ou, Byoung Chul Cho, Dong-Wan Kim, Jeeyun Lee, Jessica J. Lin, V. Zhu, M. Ahn, D. Camidge, Judy Nguyen, D. Zhai, W. Deng, Zhongdong Huang, E. Rogers, Juliet Liu, J. Whitten, John K Lim, S. Stopatschinskaja, David M. Hyman, R. Doebele, J. Cui, A. Shaw   +21 more
semanticscholar   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Influence Of Temperature Shift After Flowering on Dry Matter Partitioning In Two Cultivars of Snap Bean (Phaseolus Vulgaris)That Differ In Heat Tolerance

Plant Production Science, 2007
The Partitioning of Dry Matter (Ratio of Dry Weight of Individual Parts To That of Total Dry Matter) Was Analyzed In Snap Bean Cultivars, Haibushi, A Heat-Tolerant Cultivar, and Kentucky Wonder, A Heat-Sensitive Cultivar, At Four Temperatures After ...
Hide Omae, Ashok Kumar, Kouichi Kashiwaba, Mariko Shono   +3 more
doaj   +1 more source

From the experience of forming research competence in independent work of students in process of studying history of Russia [PDF]

Омский научный вестник: Серия "Общество. История. Современность", 2018
The article describes the analysis of the experience of organizing a written homework assignment on the topic «My relatives in the Great Patriotic War of 1941–1945» by the students of the first courses of OmSTU.
M. I. Mashkarin
doaj   +1 more source

Ce que nous dit l'étude d'une recherche de Kepler de l'influence d'une relation singulière aux objets naturalisés [PDF]

, 2016
International audienceLa question des articulations entre histoire, épistémologie et didactique est suffisamment riche pour être source inépuisable de réflexion.
Front, Mathias
core   +1 more source

Statistical properties of single-file diffusion front

, 2007
Statistical properties of the front of a semi-infinite system of single-file diffusion (one dimensional system where particles cannot pass each other, but in-between collisions each one independently follow diffusive motion) are investigated.
Sabhapandit, Sanjib
core   +2 more sources