Results 41 to 50 of about 1,238,201 (244)
From the experience of forming research competence in independent work of students in process of studying history of Russia [PDF]
Омский научный вестник: Серия "Общество. История. Современность", 2018 The article describes the analysis of the experience of organizing a written homework assignment on the topic «My relatives in the Great Patriotic War of 1941–1945» by the students of the first courses of OmSTU.
M. I. Mashkarin
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Diversity and Distributions, 2016 Line‐field confocal optical coherence tomography is a new imaging technique providing in vivo three‐dimensional images of the skin. Its spatial resolution allows standard measurements as SC/epidermis thicknesses or dermal‐epidermal junction undulation as well as innovative quantification of epidermis down to the cellular level based on artificial ...
Julie Chauvel‐Picard +21 more
openaire +2 more sources
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Region Information-Based ROI Extraction by Multi-Initial Fast Marching Algorithm
EURASIP Journal on Advances in Signal Processing, 2004 Region of interest (ROI) plays an important role in medical image analysis. In this paper, a new approach to ROI extraction based on the curve evolution is proposed.
Youmin Guo +4 more
doaj +1 more source
Early‐Phase Research in Pediatric Neuro‐Oncology
Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source