Results 231 to 240 of about 97,817 (302)

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Understanding perceptions of ophthalmology residents on pursuing a uveitis fellowship. [PDF]

Front Ophthalmol (Lausanne)
Bosque L, Gonzales J, Kodati S, Berkenstock M.   +3 more
europepmc   +1 more source

Brain‐Computer Interface Training Fosters Perceptual Skills to Detect Errors

Advanced Science, EarlyView.
Accurate perception of visuomotor errors underpins motor precision and learning, yet conventional behavioral training fails to improve sensitivity to subtle errors. Real‐time EEG‐based brain‐computer interface feedback targeting the error positivity component enhances perceptual learning of small errors.
Deland H. Liu, Fumiaki Iwane, Minsu Zhang, Leonardo G. Cohen, José del R. Millán   +4 more
wiley   +1 more source

Management of a complicated crown root fractured tooth via intentional replantation with 180° rotation: a 4-year case report. [PDF]

Front Dent Med
Wang J, Wang Y, Lin K, Han R, Ma L.
europepmc   +1 more source

Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond

Advanced Science, EarlyView.
Longitudinal, noninvasive in vivo imaging is crucial for studying brain physiology. Advances in transcranial optical windows and multiphoton microscopy have improved imaging depth, but their performance often deteriorates over time. This work investigated various transcranial window approaches and found that skull regrowth limits image quality.
Yiming Fu, Gewei Yan, Zhentao She, Yingzhu He, Kangqi Liu, Jianan Qu   +5 more
wiley   +1 more source

The effect of complex double-axis rotation model on GABAergic neurons in caudal ventrolateral medulla of rats along the vestibulo-sympathetic reflex pathway. [PDF]

Front Neuroanat
Qi J, Chen C, Gao Q.
europepmc   +1 more source

Enhanced Mechanical Properties Via Boron‐Induced Multi‐Mechanism Strengthening in (NbTaTi1.5V)100‐xBx Refractory High Entropy Alloys

Advanced Science, EarlyView.
A trace amount of boron is introduced into NbTaTi1.5V RHEA, forming a finegrained BCC+TiO+TiB microstructure. The TiB phase generates numerous dislocations, strengthening the alloy. The alloy exhibits 3610 MPa compressive fracture strength and 1060 HV microhardness, while retaining 14.8% fracture strain.
Da Wu, Bo Li, Yuzhi Shi, Cong Li, Eryong Liu, Xiaohu Hou, Yimin Gao, Tao Wu, Pucun Bai, Chenyu Liang   +9 more
wiley   +1 more source

Progress in understanding the infection mechanisms, soil microecological imbalance, and integrated control strategies of tobacco black shank. [PDF]

Front Microbiol
Wei X, Tian N, Mei W, Li J, Liu M, Zhou H, Yang Z, Yang C, Hu Y.   +8 more
europepmc   +1 more source

A Review of Trunk Rotation Mechanics in Front Crawl Swimming

Japanese journal of sciences in swimming and water exercise
openaire   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source