Results 201 to 210 of about 278,025 (305)

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Frontal lobe

, 2013
Julian Maingard, Wilson Tao, Yvette Mellam   +2 more
openaire   +1 more source

Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy. The molecular heterogeneity underlying DRE remains poorly defined, largely due to limited access to resected brain tissue and substantial genetic diversity.
Yanping Weng, Yu Ma, Wanwan Hou, Haibo Li, Yuanfeng Zhou, Rui Zhao, Hao Li, Lian Chen, Yangyang Ma, Li Jin, Yi Wang, Yu An   +11 more
wiley   +1 more source

Early alpha power in the frontal lobe area can predict delirium after cardiac surgery. [PDF]

J Cardiothorac Surg
Pei F, Yang X, Chen P, Wei J, Yao Y, Zhao Z, Wu H, Shi Y, Chen Z.   +8 more
europepmc   +1 more source

Long‐lasting remodeling of astrocytes in an Scna1+/− mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Athénaïs Genin, Alicia Janvier, Tristan Moujellil‐Legagneur, Marine Blaquière, Alexis Chaussy, Romane Privé, Fabrice Duprat, Massimo Mantegazza, Etienne Audinat, Nicola Marchi, Noémie Cresto   +10 more
wiley   +1 more source

Gait and frontal lobe function become associated in patients with idiopathic normal pressure hydrocephalus after shunt surgery. [PDF]

Front Neurol
Ishikawa M, Mori E, Kazui H.
europepmc   +1 more source

Contralateral language network integration predicts and protects against naming decline after temporal lobe resection

Epilepsia, EarlyView.
Abstract Objective Anterior temporal lobe resection (ATLR) is an effective treatment for drug‐resistant temporal lobe epilepsy (TLE) but carries a substantial risk of language impairment, particularly in naming. Understanding and predicting the impact of ATLR on language functions remains a major clinical challenge.
Karl‐Heinz Nenning, Karin Trimmel, Lisa Bartha‐Doering, Marc Berger, Matthias J. Koepp, Georg Langs, Gregor Kasprian, John S. Duncan, Silvia B. Bonelli   +8 more
wiley   +1 more source

Asymmetric efficacy of VNS within a single patient with bilateral focal frontal lobe epilepsy: A case report. [PDF]

Acta Neurochir (Wien)
Kumon M, Nakae S, Kojima D, Kawase N, Hirose Y.   +4 more
europepmc   +1 more source

Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) causes drug‐resistant epilepsy requiring presurgical evaluation. Invasive electroencephalographic (EEG) studies demonstrate that sleep modulates epileptic activity, including interictal epileptiform discharges (IEDs), fast oscillations (FOs) in the beta (14–40 Hz) and gamma (40–80 Hz) frequency bands ...
Marcel Heers, Jawata Afnan, Christoph Braun, Christophe Grova, Dirk‐Matthias Altenmüller, Bernhard J. Steinhoff, Matthias Dümpelmann, Theo Demerath, Horst Urbach, Silke Ethofer, Markus Siegel, Andreas Schulze‐Bonhage, Holger Lerche, Yiwen Li Hegner   +13 more
wiley   +1 more source

tDCS-induced enhancement of cognitive flexibility in autism: role of frontal lobe and associated neural circuits. [PDF]

Front Behav Neurosci
Han Y, Dong A, Xia C, Zhang Z, Hu W, He T, Cui X, Xu C, Xu H, Zhou Z, Cheng D, Zhang S, Li L, Tang Y, Zheng P, Dong X.   +15 more
europepmc   +1 more source