Results 271 to 280 of about 183,256 (304)

FLABRA, frontline approach for BRCA testing in ovarian cancer (OC) treatment naïve population: A Latin America (LA) epidemiologic study.

Journal of Clinical Oncology, 2019
e17050 Background: The majority of OC cases are sporadic, but it is estimated that in 17%, germline mutations in BRCA1 or BRCA2 genes can be identified. BRCA mutated OC has distinct clinical characteristics, increased sensitivity to platinum and non-platinum agents, and to DNA damage repair (DDR) targeting agents like PARP inhibitors.
Susana Beatriz Goncalves, Gonzalo Giornelli, Marcelo Horacio Pereira, Dolores Gallardo-Rincon, Maria Del Pilar Estevez-Diz   +4 more
openaire   +1 more source

Frontline Maintenance Olaparib Therapy for Brca/Hrd-Positive Advanced Epithelial Ovarian Cancer: Real-World Data Analysis in Matched Population

Journal of Heart and Vasculature, 2023
Background: introduction of the poly (ADP-ribose) polymerase (PARP) inhibitors to clinical practice remarkably improved outcomes for advanced epithelial ovarian cancer (EOC) patients. We conducted this study to evaluate efficacy of frontline maintenance olaparib therapy in BRCA-mutated and/or HRD-positive EOC patients in real-world practice setting ...
openaire   +1 more source

Venetoclax-obinutuzumab in frontline and R/R CLL: Outcomes compared to age- and sex-matched general population

Blood
Abstract Background: The synergistic mechanisms of BCL-2 inhibitors and CD20-directed antibodies in the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) often lead to deep and durable responses.
Lauren Pomerantz, Sameer Parikh, Kari Rabe, Paul Hampel, Lindsey Roeker, Saad Kenderian, Neil Kay, Rachel Bailen, Amber Koehler, Catherine Coddington, Amy Behnken, Jose Leis, Talal Hilal, Mazie Tsang, Ricardo Parrondo, Susan Schwager, Sara Achenbach, Cinthya Mendoza Zepeda, Min Shi, Curtis Hanson, Susan Slager, Esteban Braggio, Yucai Wang   +22 more
openaire   +1 more source

“Eroding trust in the state and in frontline workers can become a catalyst for the rise of populism”

Gabriela Spanghero Lotta, Professor of Public Administration and Government at Getulio Vargas Foundation (FGV) in São Paulo, Brazil, gives a Special Lecture at the IAB on 5 February 2024. In this accompanying interview, Lotta explores the dynamics of citizen-state interactions in Latin America, outlines the role of frontline workers in dealing with ...
openaire   +1 more source

The impact of frontline risk-adapted strategy on the overall survival (OS) of patients with newly diagnosed multiple myeloma (MM): A population study in Singapore (SG).

Journal of Clinical Oncology, 2011
8081 Background: MM is clinically heterogeneous and risk stratification is vital for prognostication and informing treatment.
D. C. Tan, K. H. Ong, L. P. Koh, S. S. Wong, M. T. Khin, L. H. Lee, Y. T. Goh, W. J. Chng   +7 more
openaire   +1 more source

The Impact of Populism on Individual-level Felt Accountability and the Mediating Role of Policy Meaningfulness: A Case of Frontline Childcare Teachers

KOREAN SOCIETY AND PUBLIC ADMINISTRACTION, 2023
Kyunghee Lee, Kwangseon Hwang
openaire   +1 more source

Resource integration and dynamic capability of frontline employee during COVID-19 pandemic: From value creation and engineering management perspectives

Technological Forecasting and Social Change, 2022
Sheshadri Chatterjee, Ranjan Chaudhuri, Ajay Kumar   +2 more
exaly  

Frontline: Working to include London's excluded populations

The Lancet, 2016
openaire   +2 more sources

40% of Australia’s unvaccinated population will soon be kids under 5. Childcare will be the next COVID frontline

2021
Peter Hurley, Maximilian Courten, Jora Broerse   +2 more
openaire   +1 more source

Ethical Climate at the Frontline: A Meta-Analytic Evaluation

Journal of Service Research, 2020
Scott B Friend, Fernando Jaramillo, Jeff S Johnson   +2 more
exaly