Results 101 to 110 of about 272,656 (304)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Review of the Non-Uniform Frosting/Defrosting Characteristics of Air-Cooled Refrigerator Evaporators

Zhileng xuebao
Non-uniform frost is a significant feature of evaporator surface frost in air-cooled refrigerators. It is also one of the important causative factors leading to evaporator performance degradation.
HAN Xudong, ZHANG Xinyi Wang Han, ZHAO Rijing, HUANG Dong   +3 more
doaj  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

A whole-chain technical system for multi-factor coupling mechanism, risk grading and control of frost damage in cold-region tunnels

Case Studies in Thermal Engineering
Amid the predicament of repeated frost damage in cold-region tunnels, the multi-factor coupling mechanism of such damage and precise evaluation based on segmentation and grading have received inadequate attention.
Xin Zhao, Hongwei Zhang, Xueying Wang, Hao Zheng   +3 more
doaj   +1 more source

Technical evaluation report, AGARD Fluid Dynamics Panel Symposium on Effects of Adverse Weather on Aerodynamics [PDF]

The purpose of the meeting on Effects of Adverse Weather on Aerodynamics was to provide an update of the stae-of-the-art with respect to the prediction, simulation, and measurement of the effects of icing, anti-icing fluids, and various precipitation on ...
Reinmann, J. J.
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Study on Frost Heave and Thaw Settlement Characteristics of Sanya Estuary Channel Soil Layer

Applied Sciences
In order to explore the frost heave and thaw settlement characteristics of soil layers in the Sanya Estuary Channel Project, the frost heave rate and thaw settlement coefficient of gravel sand, fine sand, silty clay, and clay are obtained.
Xiuwen Wu, Jun Hu, Junxin Shi, Hui Xiang, Jiangtao Xia   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Review on the Non-Uniform Frosting/Defrosting Characteristics of Air-Cooled Refrigerator Evaporators

Zhileng xuebao
Non-uniform frost is a significant feature of evaporator surface frost in air-cooled refrigerators, and it is also one of the important causative factors leading to evaporator performance degradation. This paper undertakes a review of the extant research
HAN Xudong, ZHANG Xinyi, WANG Han, ZHAO Rijing, HUANG Dong   +4 more
doaj  

Numerical Simulation on Frost of Cryogenic Finned-Tube Vaporizer Based on Fractal Theory

Zhileng xuebao, 2012
A model of frost formation and growth on the cryogenic surface of finned-tube vaporizer was proposed based on Diffusion Limited Aggregation (DLA) model, and through controlling the times of program running, the simulation on the different stages of frost
Chen Shuping, Yao Shuting, Xie Fushou, Han Hongyin   +3 more
doaj