Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran +10 more
wiley +1 more source
Effect of Mindfulness Training on the Clinical Pregnancy Rate in Women Undergoing Frozen Embryo Transfer: Study Protocol for a Single-Center, Open-Label, Randomized Controlled Trial. [PDF]
Yi S +8 more
europepmc +1 more source
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang +14 more
wiley +1 more source
Incidence of Retained Products of Conception Following Hormone Replacement Versus Natural Cycles in Frozen Embryo Transfer. [PDF]
Shimada A +8 more
europepmc +1 more source
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source
Impact of adenomyosis on pregnancy outcomes following frozen embryo transfer: development and validation of a single-center clinical predictive model. [PDF]
Chen H +5 more
europepmc +1 more source
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang +20 more
wiley +1 more source
Comparison of pregnancy outcomes and vaginal microbiota in women with endometriosis undergoing frozen embryo transfer using letrozole combined with HMG versus hormone replacement therapy with GnRH-a pretreatment. [PDF]
Zhang J +6 more
europepmc +1 more source
Machine learning interatomic potentials bridge quantum accuracy and computational efficiency for materials discovery. Architectures from Gaussian process regression to equivariant graph neural networks, training strategies including active learning and foundation models, and applications in solid‐state electrolytes, batteries, electrocatalysts ...
In Kee Park +19 more
wiley +1 more source

