Results 261 to 270 of about 334,320 (345)
Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu +6 more
wiley +1 more source
Polyphenol diet and exercise as neuroprotective factors in a Drosophila model of Alzheimer's disease
Animal Models and Experimental Medicine, EarlyView.Moderate exercise and low‐dose ellagic acid supplementation improved motor performance, learning, and longevity in a transgenic Drosophila model of Alzheimer's disease. Both interventions showed hormetic effects—that is, beneficial at low levels, but detrimental at higher intensities or doses.
Michelle Morgan +2 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen +12 more
wiley +1 more source
Establishment of a novel cynomolgus monkey model of hyperuricemia
Animal Models and Experimental Medicine, EarlyView.We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang +12 more
wiley +1 more source
Challenges of modeling pristane‐induced lupus in non‐human primates
Animal Models and Experimental Medicine, EarlyView.Systemic lupus erythematosus (SLE) in cynomolgus monkeys was modeled by two intraperitoneal injections of pristane at a dose of 3.5 mL/kg, administered at weeks 1 and 23. Serum samples from all monkeys that received pristane tested positive for antinuclear antibodies.
Elena Vladimirovna Vinogradova +5 more
wiley +1 more source
SmartSnacks: AI-Driven Fruit Freshness & Nutrition Detection System
B G Channabasavanna
openalex +1 more source
Solar Flow Synthesis of Polymer Nanoparticles: Scaling Local Experiments to Global Potential
Angewandte Chemie, EarlyView.The large‐scale sunlight‐induced photochemical synthesis of polymer nanoparticles based on the Diels–Alder step‐growth polymerization of a bismaleimide and a difunctional o‐methylbenzaldehyde in a self‐built solar flow reactor is introduced. Furthermore, a framework is established to translate sunlight‐driven experimental results globally—validated in ...
Jochen A. Kammerer +7 more
wiley +2 more sources
Annals of Neurology, EarlyView.Objective Behavior and motor manifestations are distinctive yet often overlooked features of epileptic seizures. Seizures can result in transient disruptions in motor control, often organized into specific behavioral sequences that can inform seizure types, onset zones, and outcomes.
Yuyan Shen +8 more
wiley +1 more source
Unexpected Dual Function of Plant YUCCA Enzymes Links Chlorophyll Catabolism to Auxin Homeostasis
Angewandte Chemie, EarlyView.YUCCA enzymes are well known to catalyze the main step of auxin biosynthesis in plants. Here, a hitherto undescribed dual function was discovered, revealing that some YUCCAs also act in chlorophyll degradation. In vitro feedback regulation furthermore suggests a link between chlorophyll degradation and hormone homeostasis and a physiological role of ...
Sina Rütschlin +6 more
wiley +2 more sources
Evaluating Real-Time PCR to Quantify Drosophila suzukii Infestation of Fruit Crops. [PDF]
InsectsGullickson MG +4 more
europepmc +1 more source