T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections. [PDF]
The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV‐negative, tuberculin‐positive volunteers with latent M.tuberculosis infection and only weak responses in HIV‐negative tuberculosis patients.
Launois P +6 more
europepmc +2 more sources
Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy [PDF]
Post-exposure prophylaxis (PEP) for leprosy is administered as one single dose of rifampicin (SDR) to the contacts of newly diagnosed leprosy patients. SDR reduces the risk of developing leprosy among contacts by around 60 % in the first 2-3 years after ...
Anthony, Richard +13 more
core +6 more sources
TB or not TB? That is the question regarding TB treatment in a remote provincial hospital in Solomon Islands [PDF]
Introduction: Tuberculosis (TB) remains a significant public health challenge in Solomon Islands. Limited healthcare resources, geography, and sociocultural beliefs, coupled with lack of laboratory diagnostic tools, leads to diagnostic and treatment ...
Denniss, Amelia +6 more
core +1 more source
The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes [PDF]
Resuscitation-promoting factor (RPF) proteins reactivate stationary-phase cultures of (G+C)-rich Gram-positive bacteria including the causative agent of tuberculosis, Mycobacterium tuberculosis.
AT Brunger +27 more
core +2 more sources
Access to Life-Saving Medicines and Intellectual Property Rights: An Ethical Assessment [PDF]
© 2011 Cambridge University Press. Online edition of the journal is available at http://journals.cambridge.org/action/displayJournal?jid=CQHDying before one’s time has been a prominent theme in classic literature and poetry.
Aquinas +20 more
core +2 more sources
Screening vaccine formulations for biological activity using fresh human whole blood. [PDF]
Understanding the relevant biological activity of any pharmaceutical formulation destined for human use is crucial. For vaccine-based formulations, activity must reflect the expected immune response, while for non-vaccine therapeutic agents, such as ...
Aboutorabian, Sepideh +9 more
core +1 more source
Traffic-Related Air Pollution and All-Cause Mortality during Tuberculosis Treatment in California. [PDF]
BackgroundAmbient air pollution and tuberculosis (TB) have an impact on public health worldwide, yet associations between the two remain uncertain.ObjectiveWe determined the impact of residential traffic on mortality during treatment of active TB ...
Brenda Jones +15 more
core +1 more source
How is the role of the tuberculosis nurse pivotal in the multidisciplinary team? [PDF]
Summary: This report will explore the significance of the tuberculosis specialist nurse, the numerous individuals that cohesively work alongside them, and how the difficulties that are encountered in multidisciplinary teams (MDTs) can be approached ...
Rach, Visha
core +1 more source
Synthesis, anti-tuberculosis activity and QSAR study of 2,4-diarylquinolines and analogous polycyclic derivatives [PDF]
The multicomponent syntheses of 2,4-di-aryl-quinolines and analogous polycyclic derivatives as anti-tuberculosis agents were described. They were prepared via Beyer and Friedländer methods under microwave irradiation in short reaction times and good ...
Asís, Silvia Elizabeth +7 more
core +1 more source
Reliability of Cobas Amplicor PCR test in detection of Mycobacterium tuberculosis in respiratory and nonorespiratory specimens [PDF]
Background/Aim. Traditional methods for detection of mycobacteria, such as microscopic examination for the presence of acid-fast bacilli and isolation of the organism by culture, have either a low sensitivity and/or specificity, or take weeks before a ...
Lepšanović Zorica +2 more
core +1 more source

