Results 11 to 20 of about 71 (35)

Abstract A57: Differential tumor cell expression of VEGF isoforms impacts on the tumor microenvironment, metastasis and radiation response in a mouse fibrosarcoma model

, 2015
We aimed to determine the influence of differential tumor cell expression of vascular endothelial growth factor A (VEGF) isoforms on lung metastasis and response to radiotherapy.
Tozer, Gillian M, Hurrell, Jack E., Lunt, Sarah Jane, Fisher, Matthew, Daniel, Rachel, R. English, William, Lefley, Diane V., Mukherjee, Debayan, Lyons, Scott K., Kanthou, Chryso   +9 more
core   +11 more sources

Radiation Effects on Mesenchymal Stem Cells in a Model of Fibrosarcoma [PDF]

, 2018
Background: Radiotherapy is a mainstay of sarcoma treatment, but can cause fibrosis, characterized by production of extra-cellular matrix proteins such as collagen by cancer-associated fibroblasts (CAFs) in the cancer stroma and surrounding normal ...
Aabed, Tariq Ahmad
core   +6 more sources

Neuropilin-1 (NRP1) and VEGF isoforms as major players in sarcoma response to vascular-targeted therapies for cancer [PDF]

, 2020
Vascular endothelial growth factor-A (VEGF) is a major target of anti-angiogenic cancer therapies. Alternative VEGFA gene splicing generates isoforms with different biological activities regulated by matrix binding and signalling through VEGF receptors ...
Thomas, Ruth H E
core   +5 more sources

Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography. [PDF]

Biomed Opt Express, 2017
Subcutaneously implanted experimental tumors in mice are commonly used in cancer research. Despite their superficial location, they remain a challenge to image noninvasively at sufficient spatial resolution for microvascular studies.
Byers RA, Fisher M, Brown NJ, Tozer GM, Matcher SJ.   +4 more
europepmc   +2 more sources

Endogenous VEGF isoform expression regulates tumour cell motility [PDF]

, 2013
Background: Vascular endothelial growth factor-A (VEGF) is produced by most cancer cells as multiple alternatively spliced isoforms, which display distinct receptor and matrix binding characteristics.
Dachs, G. U., Lefley, D. V., Kanthou, C., Reyes-Aldasoro, C. C., English, W. R.   +4 more
core   +4 more sources

Characterization of the role of VEGFA isoforms in cell migration and metastasis using engineered microenvironments [PDF]

, 2023
Background: Mortality in cancer patients is predominantly caused by metastasis. Understanding mechanisms that lead to cancer cells gaining metastatic potential may lead to novel therapies that could prevent metastasis and improve overall survival ...
Lee, Yu-Chin
core   +4 more sources

Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma [PDF]

, 2017
Elevated plasma concentrations of soluble VEGFA isoforms are associated with poor prognosis in parallel with improved response to treatment with the anti-VEGFA antibody bevacizumab.
Diane V. Lefley, Karina Bingham, Hurrell, J.E., Lyons, Scott K., Kanthou, Chryso, Fisher, M., Fisher, M., Kanthou, C., Lyons, S. K., Bingham, K., Bingham, K., Fisher, Matthew, Jack E. Hurrell, Chryso Kanthou, Lee, Yu-Chin, Dhingra, M., Dhingra, M., Lee, Y-C., Scott K. Lyons, William R. English, Mohit Dhingra, Lunt, S.J., Lee, Y. C., Hurrell, Jack E., Hurrell, J. E., Kanthou, C., Matthew Fisher, Lefley, Diane V., Dhingra, Mohit, Lyons, S.K., Gillian M. Tozer, English, W. R., English, William R., English, W.R., Tozer, G. M., Lefley, D.V., Sarah Jane Lunt, Lunt, Sarah Jane, Bingham, Karina, Lunt, S. J., Yu-Chin Lee, Lefley, D. V., Tozer, G.M.   +42 more
core   +1 more source

Supplementary Figures from Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma

, 2017
The supplementary data file contains the following data and figures: Fig S1- CD31 and CD34 co-localize to the vasculature in fs120-LS and fs188-LS subcutaneous tumors.
Mohit Dhingra (9611098), William R. English (14924792), Matthew Fisher (167773), Scott K. Lyons (14833363), Karina Bingham (14924798), Jack E. Hurrell (14924801), Gillian M. Tozer (14887551), Diane V. Lefley (11576560), Sarah Jane Lunt (14924795), Chryso Kanthou (22774), Yu-Chin Lee (344345)   +10 more
core   +1 more source

Colonies formed by fibrosarcoma cells grown in soft agar.

, 2014
Number of colonies in agar are means of three independent experiments ± SEM ...
Olga Greco (614634), Claudia Coralli-Foxon (614633), Diane V. Lefley (614631), Gillian M. Tozer (167783), Constantino C. Reyes-Aldasoro (324791), William R. English (184202), Andrew J. Steele (614632), Sofia A. Dos Santos (614635), Sheila Harris (77307), Chryso Kanthou (22774), Gabi U. Dachs (614630)   +10 more
core   +1 more source

Schematic of proposed signalling interactions and morphological and motility characteristics of fibrosarcomas expressing single VEGF isoforms.

, 2014
Differences in PI3K/AKT, Ras/Raf/MEK/ERK and JAK/Stat3 signalling between fswt/fs188 and fs164/fs120 cells are shown. Upregulation/downregulation of activities or levels of expression of individual proteins are indicated by up or down arrows.
Olga Greco (614634), Claudia Coralli-Foxon (614633), Diane V. Lefley (614631), Gillian M. Tozer (167783), Constantino C. Reyes-Aldasoro (324791), William R. English (184202), Andrew J. Steele (614632), Sofia A. Dos Santos (614635), Sheila Harris (77307), Chryso Kanthou (22774), Gabi U. Dachs (614630)   +10 more
core   +1 more source