Results 31 to 40 of about 215 (59)

Monovinyl sulfone beta-cyclodextrin. A flexible drug carrier system [PDF]

, 2014
Cyclodextrins have been conjugated to target various receptors and have also been functionalized with carbohydrates for targeting specific organs. However, this approach is based on a rigid design that implies the ad hoc synthesis of each cyclodextrin ...
del Castillo, T, Garcia-Salcedo, JA, Lopez-Jaramillo, FJ, Magez, Stefan, Marales-Sanfrutos, J, Santoyo-Gonzalez, F   +5 more
core   +2 more sources

Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors : toward the development of novel therapies for African sleeping sickness [PDF]

, 2010
Trypanosoma brucei, the causative agent of human African trypanosomiasis, affects tens of thousands of sub-Saharan Africans. As current therapeutics are inadequate due to toxic side effects, drug resistance, and limited effectiveness, novel therapies are
Gehrig S., Maser P., Delespaux V., Vansterkenburg E. L., Blum J., Kayser O., Iten M., Priotto G., Cross G. A., Smith D. H., Schechter P. J., Shoichet B. K., Bajorath J., Abagyan R., Shaw M. P., Holden H. M., Roper J. R., Roper J. R., Mehlert A., Nolan D. P., Tetaud E., Eisenthal R., Dodson G. G., Amaro R. E., Okazaki K., Schneider G., Lin J. H., Schames J. R., Amaro R. E., Trott O., Morris G. M., Brahma A., Hay M., Feng B. Y., Surig U., Langmead C. J., Pate P. G., Kerschmann R. L., Dougherty D. A., Kerr I. D., Urbaniak M. D., Raz B., Lipinski C. A., Ghose A. K., Testa B., Dolinsky T. J., Walker R. C., Pavelites J. J., Ponder J. W., Case D. A., Jorgensen W. L., Feller S. E., Darden T., Kale L., Phillips J. C., Landon M. R., Christen M.   +56 more
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Synthesis and Antiprotozoal Activity of Dicationic 2, 6-Diphenylpyrazines and Aza-Analogues [PDF]

, 2017
Dicationic 2,6-diphenylpyrazines, aza-analogues and prodrugs were synthesized; evaluated for DNA affinity, activity against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.) in vitro, efficacy in T. b. r. STIB900 acute and T. b.
Bondada, Lavanya, Boykin, David W., Brun, Reto, Hu, Laixing, Munde, Manoj, Patel, Alpa, Wang, Michael Zhuo, Wenzler, Tanja, Wilson, W. David, Yang, Sihyung   +9 more
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Phospholipases A in Trypanosomatids [PDF]

, 2011
Phospholipases are a complex and important group of enzymes widespread in nature, that play crucial roles in diverse biochemical processes and are classified as A1, A2, C, and D.
Belaunzarán, María Laura, Lammel, Estela María, de Isola, Elvira Luisa Durante   +2 more
core   +2 more sources

Workshop summary : One Health Zoonotic Disease Prioritization for Multi-Sectoral Engagement in Uganda, Kampala, Uganda March 2\u20133, 2017 [PDF]

To best address zoonotic disease challenges in Uganda as part of the Global Health Security Agenda, a zoonotic disease prioritization workshop was held during March 2\u20133, 2017, at the Imperial Royale Hotel in Kampala.

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Framework for an Integrated Ehealth Platform with Smart Diagnostic Engine for Improved Healthcare Access for Rural Dwellers [PDF]

, 2020
The healthcare challenges faced by rural dwellers in developing nations, especially those in the African continent include a lack of sufficient workforce, especially doctors, lack of healthcare facilities and access to the required medications.
Idachaba, F.E., Idachaba, Mercy E.
core  

Nodding Syndrome – An Investment Case for Global Health? [PDF]

, 2018
submittedVersio
Schmutzhard, E, Spencer, Peter, Winkler, Andrea Sylvia, Årdal, Christine Oline   +3 more
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Effects of some natural leads on Trypanosoma and Leishmania strains [PDF]

, 2019
Well-known medical herbal compounds including apigenin, daidzein, phyllanthin and tyramine were assessed against Trypanosoma and Leishmania protozoans.
Alkhaldi, A.A.M., Bukhari, S.N.A., De Koning, H.P.   +2 more
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A Brief History of Tsetse Control Methods in Zimbabwe and Possible Effects of Climate Change on Their Distribution [PDF]

, 2017
African trypanosomiasis, which affects wildlife, domesticated animals and humans, remains widespread across Africa. Approximately 8 million km2, covering 37 African counties, are infested with tsetse flies (Glossina) that carry the disease (Allsopp 2001).
Pilossof, Rory
core   +2 more sources

Deep learning enhanced mobile-phone microscopy

, 2017
Mobile-phones have facilitated the creation of field-portable, cost-effective imaging and sensing technologies that approach laboratory-grade instrument performance. However, the optical imaging interfaces of mobile-phones are not designed for microscopy
Gorocs, Zoltan, Gunaydin, Harun, Koydemir, Hatice Ceylan, Liang, Kyle, Ozcan, Aydogan, Ren, Zhengshuang, Rivenson, Yair, Tseng, Derek, Wang, Hongda, Wei, Zhensong, Zhang, Yibo   +10 more
core   +2 more sources