The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis. [PDF]
Adv Sci (Weinh)SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Guo S +5 more
europepmc +2 more sources
Extracellular Vesicle-Transferred ATP-Citrate Lyase Induces Monocyte Differentiation Toward Tumor-Associated Macrophages and Fuels Hepatocellular Carcinoma Progression. [PDF]
Adv Sci (Weinh)Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Liu Z +11 more
europepmc +2 more sources
HIF-1α knockdown attenuates inflammation and oxidative stress in ischemic stroke male rats via CXCR4/NF-κB pathway. [PDF]
Brain BehavIn this study, HIF‐1α‐specific short hairpin RNA is used to silence HIF‐1α. HIF‐1α silencing attenuates inflammation and oxidative stress in ischemic stroke male rats and oxygen‐glucose deprivation/reoxygenation (OGD/R) mice hippocampal cells via the CXCR4/NF‐κB pathway.
Chen G +5 more
europepmc +2 more sources
ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC-I Antigen Presentation That Promotes Tumor Immune Evasion. [PDF]
Adv Sci (Weinh)ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Zhao L +12 more
europepmc +2 more sources
The Food Safety Modernization Act of 2011: Final Rule for Preventive Controls for Human Food
EDIS, 2018 This 7-page fact sheet is one in a series covering the different rules promulgated under the new Food Safety Modernization Act (FSMA), which was signed into law on January 4, 2011.
Jessica Lepper +4 more
doaj +5 more sources
IMP4 Silencing Inhibits the Malignancy of Lung Adenocarcinoma via ERK Pathway
Journal of Oncology, Volume 2022, Issue 1, 2022., 2022 Our study aimed to elucidate the function of IMP U3 small nucleolar ribonucleoprotein 4 (IMP4) in lung adenocarcinoma (LUAD) and its potential molecular mechanisms. Cell counting kit‐8, 5‐ethynyl‐20‐deoxyuridine, flow cytometry, wound healing, and transwell assays were performed to examine the biological behaviour of LUAD cells.
Ruzhen Li +7 more
wiley +1 more source
Protocol for isolation and analysis of the leukemia stem cells in BCR-ABL-driven chronic myelogenous leukemia mice. [PDF]
STAR Protoc, 2023 Liu C, Lin X, Jin Y, Pan J.
europepmc +1 more source
Bu tez çalışmasında, iplik dayanımını etkileyen süreç parametrelerinin eniyilenmesi amaçlanmıştır. İplik dayanımını belirleyen, ölçülebilir özelliğe sahip çıktı parametreleri; mukavemet ve uzama yüzdesi olarak belirlenmiştir.
Süleyman Demirel Üniversitesi. Fen Bilimleri Enstitüsü. Endüstri Mühendisliği Anabilim Dalı. 9372 issuing body +2 more
core
Identification of three conserved linear B cell epitopes on the SARS-CoV-2 spike protein. [PDF]
Emerg Microbes Infect, 2022 Wang A +10 more
europepmc +1 more source
Activation of Young LINE-1 Elements by CRISPRa. [PDF]
Int J Mol Sci, 2023 Tong B, Sun Y.
europepmc +1 more source