Results 81 to 90 of about 51,522 (266)

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Black soldier fly larvae composting as a bioremediation approach for heavy metals and pathogens in fecal sludge cake

Discover Environment
Black Soldier Fly Larvae (BSFL) composting is increasingly explored as a sustainable strategy to treat organic waste. This study assessed the potential of BSFL to reduce heavy metals and pathogens in fecal sludge cake (FSC) co-composted with fruit and ...
Agnes Nalunga, Allan John Komakech, Jeninah Karungi, Isa Kabenge, Therese Schwarzböck   +4 more
doaj   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Printed Flexible WO3‐Based Supercapacitors for Powering Low‐Powered Electronics in Wearable Devices and Energy Autonomous Temperature Monitoring

Advanced Electronic Materials, EarlyView.
This study represents one of the systematic demonstrations of a screen‐printed, flexible WO3‐based supercapacitor, exhibiting excellent charge‐storage performance for powering wearable electronics. The device shows a specific capacitance of 3.44 F g−1 and an energy density of 0.302 Wh kg−1 at 0.05 mA, which enable to operate multiple wearable ...
Jithin Kanathedath, Adarsh Sivan Pillai, Febin Paul, Prasutha Rani Markapudi, Nazmi Sellami, Firdaus Muhammad‐Sukki, Libu Manjakkal   +6 more
wiley   +1 more source

Dielectric Elastomer Actuators as Safe and Effective Tools for Mechanostimulation of Human Cells

Advanced Intelligent Systems, EarlyView.
Replicating physiological forces is crucial for realistic cell models. Dielectric elastomer actuators (DEAs) offer a soft alternative, though their high voltages raised toxicity concerns. We demonstrate that DEA stimulation causes no cell damage, cell death or cell‐cycle disruption, while activating mechanosensitive responses.
Simon Holzer, Chaimae Bahou, Noe Syfrig, Katia Monastyrskaya, Yoan Civet, Ali Hashemi Gheinani, Yves Perriard   +6 more
wiley   +1 more source

A Ship Emission Monitoring Option for Fuel Sulphur Content Measurement in Complex Environments

Journal of Marine Science and Engineering
Limiting the fuel sulphur content (FSC) of ships can significantly reduce the harm caused by ship emissions, and analyzing ship exhaust gas to estimate FSC is a rapid, efficient, and low-cost monitoring method.
Fan Zhou, Xiaojia Lin, Liwei Hou
doaj   +1 more source

Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice

American Journal of Hematology, EarlyView.
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim, Nuttanan Pholngam, Rattanawan Thubthed, Tiwaporn Nualkaew, Saovaros Svasti, Pornthip Chaichompoo, Kai Kysenius, Peter J. Crouch, Sibylle Dames, Mona Eisermann, Alberto Martinez, Ute Schaeper, Jim Vadolas, George Grigoriadis   +13 more
wiley   +1 more source

Preparation, Physicochemical Characteristics and Rheological Properties of Forster (Trachiocephalus myops) Scale Collagen

Shipin gongye ke-ji
Fish collagen has significant market application potential, however, current fish collagen products do not meet the consumer demand. To develop new sources of collagen, Forster scales were utilized as raw material to prepare Forster scale collagen (FSC ...
Cong KE, Jianlin HE, Yushuang LI, Yan ZHENG, Xiyuan GAO, Hetong LIN, Junde CHEN   +6 more
doaj   +1 more source

IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α

Animal Models and Experimental Medicine, EarlyView.
IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. Abstract Background The purpose is to define the contribution of the interferon regulatory factor‐1–dual‐specificity tyrosine phosphorylation‐regulated kinase 1α (IRF‐1–DYRK1α) axis to hepatocellular ferroptosis during liver ischemia/reperfusion injury ...
Jinping Zhang, Jinming Zhang, Siyuan Song, Mingyang Li, Liying Sun, Zhijun Zhu, Dongdong Lin   +6 more
wiley   +1 more source

Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection

Animal Models and Experimental Medicine, EarlyView.
A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang, Shicheng Wan, Yanmin Guo, Hongyu Han, Fei Luo, Dongmei Jiang, Xiaorong Yang, Quanhai Pang, Haisheng Yu, Jinlian Hua   +9 more
wiley   +1 more source