Results 141 to 150 of about 143,522 (274)

Multi-objective contextual bandits in recommendation systems for smart tourism

Scientific Reports
In the context of smart tourism, recommender systems play a pivotal role in enhancing the personalization and quality of travel experiences. Tourists often face challenges in decision-making due to information overload.
Sara Qassimi, Said Rakrak
doaj   +1 more source

Downregulation of EPAS1 and EGLN1 mRNA Expression Associated With High‐Altitude Adaptive Genetic Variants in Sherpa Highlanders

Annals of Human Genetics, EarlyView.
ABSTRACT Background and Aims Sherpa highlanders exhibit remarkable tolerance to hypoxia, most likely due to genetic adaptations shaped by natural selection at high altitude. This study examined the roles of endothelial PAS domain protein 1 (EPAS1) and egl‐9 family hypoxia‐inducible factor 1 (EGLN1) in the genetic mechanisms underlying this adaptation ...
Yunden Droma, Fengming Yue, Masao Ota, Nobumitsu Kobayashi, Yoshiaki Kitaguchi, Masayuki Hanaoka   +5 more
wiley   +1 more source

Characterising PRPF31‐associated retinal dystrophy: Clinical insights from baseline data in a natural history study

Acta Ophthalmologica, EarlyView.
Abstract Purpose To characterise the baseline clinical features and genotypes of adults with pre‐mRNA processing factor 31 (PRPF31)‐associated retinal dystrophy (RD) enrolled in a prospective, multicentre 4‐year natural history study, and to explore correlations between selected baseline parameters.
Kathrine Olaussen Eriksen, Jon Roger Eidet, Ulrika Kjellström, Jacopo Baldesi, Ragnheidur Bragadóttir, Leonardo Colombo, Josephine Prener Holtan   +6 more
wiley   +1 more source

IGZO-Based First Spike Timing Tactile Encoders and Coupling-Enhanced Transistor Synapses for Efficient Spiking Neural Networks. [PDF]

Adv Sci (Weinh)
Here, a bioinspired light‐accelerated neuromorphic system that seamlessly links tactile sensing, first‐spike‐timing (FST) encoding, and light–electric synaptic learning. Pressure stimuli trigger FST spikes in dual‐gate PDTFTs, while GaOx/IGZO hetero‐synapses exhibit enhanced memory under optical–electrical co‐activation, enabling spiking neural ...
Cai D, Wang J, Zhao T, Shen M, Liu Y, Zhang T, Zhang F, Wang Y, Jiang Y, Gu D.   +9 more
europepmc   +2 more sources

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

British Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Unlocking female CEOs' contribution to the internationalization of family‐controlled firms

European Management Review, EarlyView.
Abstract Are female CEOs better or worse than male CEOs for the internationalization of family‐controlled firms? By addressing this question, we draw on Upper Echelons Theory (UET) and complement it with insights from the Behavioral Theory of the Firm (BTF) to examine the moderating role of governance and ownership openness. Using a large panel of 2150
Alfredo D'Angelo, Fabio Quarato, Domenico Rocco Cambrea, Pasquale Latella   +3 more
wiley   +1 more source

Improving Melanoma Risk Stratification of Skin Color Type by Polygenic Scores of Skin Color and Melanoma

International Journal of Dermatology, EarlyView.
ABSTRACT Background The Fitzpatrick skin type (FST) is commonly used in clinical settings to stratify melanoma risk across different skin types. However, it is subjective and does not capture intra‐type variability in risk. These limitations are particularly evident among lighter‐skinned individuals, who constitute the majority of those with European ...
Huy Tran, Annabelle Ashworth, Zhuqing Shi, Jun Wei, S. Lilly Zheng, Ross M. Levy, Luzheng Liu, David Duggan, Aleksandar Sekulic, Jianfeng Xu   +9 more
wiley   +1 more source

Eye can see clearly now: Identifying the locus associated with a white‐eye mutation in honey bees (Apis mellifera)

Insect Molecular Biology, EarlyView.
We performed a community science investigation with the beekeepers nationwide to find phenotypic mutants. Alongside a beekeeper in Kentucky, we performed a GWAS to identify a region associated with a white‐eye phenotype. We identified an eight bp region in a non‐coding RNA strongly associated with white eyes.
Riley R. Shultz, Dylan K. Ryals, Phillip Patterson, Jonathan M. Nixon, Izaak R. Gilchrist, Brock A. Harpur   +5 more
wiley   +1 more source