Results 21 to 30 of about 284,202 (197)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Implementasi Alat Evaluasi Menggambar Busana di SMK Swasta Kelompok Pariwisata Kabupaten Sleman

Jurnal Pendidikan Teknologi dan Kejuruan, 2014
The objectives of the study were to determine the application procedure of the evaluation instrument of fashion drawing, to analyse the consistency of the evaluation results, and to determine the communicative reporting procedure of the evaluation ...
Sri Widarwati, Emy Budiastuti, Prapti Karomah   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RANCANGAN PENGERING ENERGI SURYA MENGGUNAKAN KOLEKTOR DAN KIPAS UNTUK PENGERINGAN KAKAO FERMENTASI

Ethos: Jurnal Penelitian dan Pengabdian kepada Masyarakat, 2017
Rancangan alat pengering surya tidak langsung menggunakan kolektor  plat datar bersirip dan kipas untuk pengeringan kakao fermentasi telah dilakukan. Kualitas produk kakao sangat ditentukan oleh kakao pasca panen yaitu proses fermentasi dan pengeringan ...
Fatimah Fatimah, Muhamad Turmuzi, Rondang Tambun, Iriany Iriany   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Lingual Pustular Psoriasis and Acrodermatitis Continua of Hallopeau Successfully Treated with Adalimumab: A Rare Case Report and Review of Oral Psoriasis

European Medical Journal Dermatology, 2018
Psoriasis is a common skin disease with various cutaneous manifestations and is classified into two clinical groups: non-pustular and pustular. Pustular psoriasis is less common than non-pustular forms of psoriasis and is particularly resistant to ...
Sarah J.J. Touyz, Melanie Pratt
doaj  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

HUBUNGAN PENGUASAAN TEORI DENGAN KETERAMPILAN MERANGKAI KELISTRIKAN OTOMOTIF

Teknologi dan Kejuruan, 2015
Penelitian ini bertujuan: (1) mendeskripsikan prestasi belajar mahasiswa pada Matakuliah (MK) Teori Kelistrikan Otomotif, dan MK Praktik Kelistrikan Otomotif, dan (2) mengungkap hubungan penguasaan teori Kelistrikan Otomotif dengan keterampilan merangkai
Sukardi Sukardi, Sunardi Sunardi, Lukas Sampe   +2 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source