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Inheritance of Fuchs' Endothelial Dystrophy
Archives of Ophthalmology, 1971Two pedigrees contain seven individuals with documented Fuchs' endothelial dystrophy. A review of all previously reported familial cases reveals one pedigree with sufficient useful data for genetic analysis. Study of these three pedigrees together with segregation analysis suggests an autosomal dominant mutation as the most likely etiology, although ...
H E, Cross +2 more
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Mechanisms of disease: Fuchs' endothelial dystrophy
Ophthalmology Clinics of North America, 2002Fuchs' endothelial dystrophy is a common disease that has been widely studied since its initial report in 1910 by Ernst Fuchs. Although its clinical course and pathologic characteristics are well described, the etiology and inheritance pattern are still ambiguous.
Sheila, Borboli, Kathryn, Colby
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Oxytalan Fibers in Fuchs' Endothelial Dystrophy
Archives of Ophthalmology, 1981• In a histochemical and electron microscopic study of nine cases of Fuchs' endothelial dystrophy, oxytalan, a component of the elastic fiber family, was found in the extracellular tissues of the cornea. Oxytalan was most abundant around but not within the guttate excrescences; it was also found beneath the epithelium, occasionally beneath Bowman's ...
R A, Alexander, I, Grierson, A, Garner
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Fuchs' endothelial dystrophy of the cornea
Survey of Ophthalmology, 1993Fuchs' endothelial dystrophy of the cornea is a significant cause of corneal blindness in the United States. The disease is characterized by a slow, continuous loss of morphologically and physiologically altered endothelial cells, eventually leading to corneal edema.
A P, Adamis +3 more
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Endothelial viral inclusions in Fuchs' corneal dystrophy
Human Pathology, 1987A case of Fuchs' corneal dystrophy is presented. The patient, a 70-year-old white woman, had bilateral decreasing vision, especially while reading and driving at night. Clinical features were characteristic of Fuchs' corneal dystrophy. Ultrastructural studies demonstrated findings in Descemet's membrane typical of those previously reported with ...
S I, Roth, E L, Stock, R, Jutabha
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Fuchs Endothelial Corneal Dystrophy and Mitochondria
Cornea, 2018Abstract: Fuchs endothelial corneal dystrophy (FECD) is a bilateral progressive corneal endothelial disease characterized by guttae, which present as partial Descemet membrane thickening, inducing corneal edema at the final stage. Oxidative stress has been reported to play an important role in the pathogenesis of FECD.
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Cytochrome oxidase activity of Fuchs' endothelial dystrophy
Current Eye Research, 1986The normal human corneal endothelial monolayer maintains stromal water equilibrium and thus, transparency, by means of a pump-leak mechanism. Water leaks into the stroma through non-tight lateral cell junctional complexes and is drawn out by an energy dependent cell membrane ion pump. We investigated the histochemical localization of cytochrome oxidase
A W, Tuberville +2 more
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Regenerative Therapy for Fuchs Endothelial Corneal Dystrophy
Cornea, 2018Purpose: Fuchs endothelial corneal dystrophy (FECD) is an acquired corneal endotheliopathy and is one of the most common indications for corneal transplantation surgery worldwide. Endothelial keratoplasty (EK) is the most popular form of corneal transplantation for FECD. In standard EK surgery, the patient's corneal endothelium
Yu Qiang, Soh, Jodhbir S, Mehta
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Fuchs’ Endothelial Dystrophy and Glaucoma
2010Fuchs’ Endothelial Dystrophy (FED) is a common disorder of the cornea that causes slow progressive endothelial degeneration with subsequent corneal edema and loss of vision in late stages. It is characterized by a thickened Descemet’s membrane (DM) from the aberrant deposition of wide-spaced collagen and the development of guttae, or posterior ...
Blair Boehmer, Clark Springs
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Genotyping methods for Fuchs corneal endothelial dystrophy
Journal Français d'OphtalmologieFuchs endothelial corneal dystrophy (FECD) is a genetic degenerative disease characterized by the progressive degradation of the corneal endothelium, often leading to vision loss. It is the leading cause of corneal transplantation in the Western world. FECD is more common in Europe and the United States, particularly among women.
D. Onitiu +9 more
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