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Fuchs Endothelial Corneal Dystrophy and Mitochondria
Cornea, 2018Abstract: Fuchs endothelial corneal dystrophy (FECD) is a bilateral progressive corneal endothelial disease characterized by guttae, which present as partial Descemet membrane thickening, inducing corneal edema at the final stage. Oxidative stress has been reported to play an important role in the pathogenesis of FECD.
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Cytochrome oxidase activity of Fuchs' endothelial dystrophy
Current Eye Research, 1986The normal human corneal endothelial monolayer maintains stromal water equilibrium and thus, transparency, by means of a pump-leak mechanism. Water leaks into the stroma through non-tight lateral cell junctional complexes and is drawn out by an energy dependent cell membrane ion pump. We investigated the histochemical localization of cytochrome oxidase
A W, Tuberville +2 more
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Regenerative Therapy for Fuchs Endothelial Corneal Dystrophy
Cornea, 2018Purpose: Fuchs endothelial corneal dystrophy (FECD) is an acquired corneal endotheliopathy and is one of the most common indications for corneal transplantation surgery worldwide. Endothelial keratoplasty (EK) is the most popular form of corneal transplantation for FECD. In standard EK surgery, the patient's corneal endothelium
Yu Qiang, Soh, Jodhbir S, Mehta
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Fuchs’ Endothelial Dystrophy and Glaucoma
2010Fuchs’ Endothelial Dystrophy (FED) is a common disorder of the cornea that causes slow progressive endothelial degeneration with subsequent corneal edema and loss of vision in late stages. It is characterized by a thickened Descemet’s membrane (DM) from the aberrant deposition of wide-spaced collagen and the development of guttae, or posterior ...
Blair Boehmer, Clark Springs
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Genotyping methods for Fuchs corneal endothelial dystrophy
Journal Français d'OphtalmologieFuchs endothelial corneal dystrophy (FECD) is a genetic degenerative disease characterized by the progressive degradation of the corneal endothelium, often leading to vision loss. It is the leading cause of corneal transplantation in the Western world. FECD is more common in Europe and the United States, particularly among women.
D. Onitiu +9 more
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Fuchs endothelial corneal dystrophy: an updated review
International OphthalmologyThe present review will summarize FECD-associated genes and pathophysiology, diagnosis, current therapeutic approaches, and future treatment perspectives.Literature review.Fuchs' endothelial corneal dystrophy (FECD) is the most common bilateral corneal dystrophy and accounts for one-third of all corneal transplants performed in the US.
Francisco Altamirano +5 more
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Endothelial keratoplasty versus penetrating keratoplasty for Fuchs endothelial dystrophy
2011Fuchs endothelial dystrophy (FED), first described by Ernst Fuchsis in 1910, is a condition in which there is premature degeneration of corneal endothelial cells. When the number of endothelial cells is reduced to a significant degree fluid begins to accumulate within the cornea.
Mayank A, Nanavaty, Alex J, Shortt
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Vision With Fuchs Endothelial Dystrophy
JAMA Ophthalmology, 2015Lucas M M, Vianna +2 more
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